Publications by authors named "Kelley Bastin"
Reactivation from latency plays a significant role in maintaining persistent lifelong Epstein-Barr virus (EBV) infection. Mechanisms governing successful activation and progression of the EBV lytic phase are not fully understood. EBV expresses multiple viral microRNAs (miRNAs) and manipulates several cellular miRNAs to support viral infection.
View Article and Find Full Text PDFArticle Synopsis
- Evaluating the risks of chemicals in mixtures, particularly polycyclic aromatic hydrocarbons (PAHs), poses major challenges for risk assessment due to their complex behaviors.
- A classification model using systems biology data from mice was applied to a human in vitro model using 3D bronchial epithelial cells, effectively categorizing PAHs based on their carcinogenic potential.
- Findings revealed that the best gene sets for identifying PAH carcinogenicity differed significantly from those responsive to benzo[a]pyrene (BAP), prompting a reevaluation of existing assumptions about PAH toxicity and highlighting the benefits of systems toxicology in hazard assessment.