Publications by authors named "Kellen Roddy"
Article Synopsis
- Researchers successfully created an infectious clone of HSV-1 by assembling its genome from 11 cloned fragments in yeast using a method called transformation associated recombination.*
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- They engineered mutations in five specific genes, which are important for the virus's structure and functionality, and discovered that certain combinations of these mutations led to "synthetic lethality," preventing the virus from replicating in specific cell lines.*
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- The study focused on the mutations of the UL16 and UL21 genes, revealing that viruses lacking both proteins showed immature capsid structures unable to mature into infectious particles, highlighting their potential roles in virus assembly.*
