Residential proximity to unconventional oil and gas development and birth defects in Ohio.

Background: Chemicals used or emitted by unconventional oil and gas development (UOGD) include reproductive/developmental toxicants. Associations between UOGD and certain birth defects were reported in a few studies, with none conducted in Ohio, which experienced a thirty-fold increase in natural gas production between 2010 and 2020.

Methods: We conducted a registry-based cohort study of 965,236 live births in Ohio from 2010 to 2017.

Unconventional Oil and Gas Development Exposure and Risk of Childhood Acute Lymphoblastic Leukemia: A Case-Control Study in Pennsylvania, 2009-2017.

Background: Unconventional oil and gas development (UOGD) releases chemicals that have been linked to cancer and childhood leukemia. Studies of UOGD exposure and childhood leukemia are extremely limited.

Objective: The objective of this study was to evaluate potential associations between residential proximity to UOGD and risk of acute lymphoblastic leukemia (ALL), the most common form of childhood leukemia, in a large regional sample using UOGD-specific metrics, including a novel metric to represent the water pathway.

Childhood asthma and household exposures to nitrogen dioxide and fine particles: a triple-crossover randomized intervention trial.

Objective: Triple-crossover randomized controlled intervention trial to test whether reduced exposure to household NO or fine particles results in reduced symptoms among children with persistent asthma.

Methods: Children ( = 126) aged 5-11 years with persistent asthma living in homes with gas stoves and levels of NO 15 ppb or greater recruited in Connecticut and Massachusetts (2015-2019) participated in an intervention involving three air cleaners configured for: (1) NO reduction: particle filtration and NO scrubbing; (2) particle filtration: HEPA filter and NO scrubbing; (3) control: particle filtration and NO scrubbing. Air cleaners were randomly assigned for 5-week treatment periods using a three-arm crossover design.

Assessing Unconventional Oil and Gas Exposure in the Appalachian Basin: Comparison of Exposure Surrogates and Residential Drinking Water Measurements.

Health studies report associations between metrics of residential proximity to unconventional oil and gas (UOG) development and adverse health endpoints. We investigated whether exposure through household groundwater is captured by existing metrics and a newly developed metric incorporating groundwater flow paths. We compared metrics with detection frequencies/concentrations of 64 organic and inorganic UOG-related chemicals/groups in residential groundwater from 255 homes (Pennsylvania = 94 and Ohio = 161).