The clinical impact of chronopharmacology on current medicine.

One of the goals of clinical pharmacology is to optimize patient treatment by adopting new treatment strategies which will increase the efficacy of the treatment and decrease the adverse effects of the drugs. In the literature, it has shown that the effectiveness and toxicity of medications can vary significantly based on when they are administered, making timing a crucial factor in treatment plans. Chronopharmacology a relatively new branch of clinical pharmacology focuses on adjusting drug administration times to enhance patient outcomes.

In Situ Lung Dust Analysis by Automated Field Emission Scanning Electron Microscopy With Energy Dispersive X-ray Spectroscopy: A Method for Assessing Inorganic Particles in Lung Tissue From Coal Miners.

Context.—: Overexposure to respirable coal mine dust can cause severe lung disease including progressive massive fibrosis (PMF). Field emission scanning electron microscopy with energy dispersive x-ray spectroscopy (FESEM-EDS) has been used for in situ lung dust particle analysis for evaluation of disease etiology.

Biochemical, biomechanical and imaging biomarkers of ischemic stroke: Time for integrative thinking.

Stroke is one of the leading causes of adult disability affecting millions of people worldwide. Post-stroke cognitive and motor impairments diminish quality of life and functional independence. There is an increased risk of having a second stroke and developing secondary conditions with long-term social and economic impacts.

The effect of vitamin D deficiency on urinary incontinence during third trimester pregnancy.

Urinary incontinence (UI) is a common problem which is associated with impaired quality of life. Vitamin D plays a crucial role for pelvic floor muscle function. The aim of this study was to investigate the effect of vitamin D deficiency on UI in pregnant women in the third trimester of pregnancy.

Respirable silica particles in coal mine dust: An image library dataset collected using scanning electron microscopy with energy dispersive X-ray spectroscopy.

This dataset comprises an image library of 282 respirable silica particles. The particles were identified in samples of respirable coal mine dust (RCMD) collected in numerous US underground mines, and samples of lab-generated respirable dust that were created using the primary dust source materials (e.g.

Thermogravimetric analysis of respirable coal mine dust for simple source apportionment.

Resurgence of coal mine dust lung diseases in the central Appalachian region of the United States and elsewhere has spurred a range of efforts to better understand respirable coal mine dust (RCMD) exposures and sources. Thermogravimetric analysis (TGA) of RCMD samples can enable the dust mass to be fractionated into three main components: coal, non-carbonate minerals, and carbonates. These are expected to approximate, respectively, the three primary dust sources in many underground mines: the coal seam being mined, the surrounding rock strata (i.

Updating "Characteristics of respirable dust in eight Appalachian coal mines: A dataset including particle size and mineralogy distributions, and metal and trace element mass concentrations" with expanded data to cover a total of 25 US mines.

A total of 171 sets respirable dust samples were collected from 25 underground coal mines in several regions of the United States. One sample from each set was analyzed by scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX) to determine particle size and mineralogy distributions. Results from the first eight mines were presented in the original dataset (Sarver et al.

THE EFFECTS OF ETANERCEPT AND CABERGOLINE ON ENDOMETRIOTIC IMPLANTS, UTERUS AND OVARIES IN RAT ENDOMETRIOSIS MODEL.

The pathophysiology of endometriosis is still unknown and treatment options remain controversial. Searches focus on angiogenesis, stem cells, immunologic and inflammatory factors. This study investigated the effects of etanercept and cabergoline on ovaries, ectopic, and eutopic endometrium in an endometriosis rat model.

Family-centeredness of services for young children with Down syndrome: an observational study from Turkey.

Background/aim: Physicians require information on the family centeredness of services for children with Down syndrome, one of the most frequently encountered disabilities in childhood. We aimed to determine the family-centeredness of services for young children with Down syndrome and using a bioecological theory framework we hypothesized that child, family and service-related factors would be associated with such services.

Materials And Methods: In a crosssectional design, children with Down syndrome seen at Ankara University Developmental Pediatrics Division (AUDPD) between February 2020 and June 2020 were included if they had received services in the community for at least 12 months.

A thermogravimetric analysis application to determine coal, carbonate, and non-carbonate minerals mass fractions in respirable mine dust.

Occupational lung diseases such as coal worker's pneumoconiosis, often called black lung, are caused by exposures to respirable coal mine dust. Dust composition is increasingly understood as an important disease factor, and it can vary significantly depending on dust source materials and generation processes. For regulatory compliance purposes, the mass concentration and quartz percentage of respirable dust are monitored in U.

Characteristics of respirable dust in eight appalachian coal mines: A dataset including particle size and mineralogy distributions, and metal and trace element mass concentrations.

Respirable dust samples were collected in several key locations of eight underground coal mines in central and northern Appalachia. In total, there were 76 unique sampling events (i.e.

Is helical tomotherapy-based intensity-modulated radiotherapy feasible and effective in bilateral synchronous breast cancer? A two-center experience.

Purpose: This study describes the early clinical results and dosimetric parameters of intensity-modulated radiation therapy (IMRT) using a tomotherapy device in patients with primary bilateral synchronous breast cancer (PSBBC).

Methods: Fourteen patients with bilateral breast cancer were treated with tomotherapy between January 2011 and October 2014. The treatment planning objectives were to cover 95% of the planning target volume using a 95% isodose, with a minimum dose of 90% and a maximum dose of 107%.

Disturbance rejection performance analyses of closed loop control systems by reference to disturbance ratio.

This study investigates disturbance rejection capacity of closed loop control systems by means of reference to disturbance ratio (RDR). The RDR analysis calculates the ratio of reference signal energy to disturbance signal energy at the system output and provides a quantitative evaluation of disturbance rejection performance of control systems on the bases of communication channel limitations. Essentially, RDR provides a straightforward analytical method for the comparison and improvement of implicit disturbance rejection capacity of closed loop control systems.

Can mean platelet volume be a new risk factor in portal venous thrombosis?

Background: The aim of this study was to discuss the possibility of mean platelet volume (MPV) being a new risk factor in the etiology of portal venous thrombosis (PVT).

Methods: Study participants were categorized into 2 different groups: group I, control group (n = 35) and group II, PVT group (n = 34). Demographic data and MPV values were recorded retrospectively.

Sigmoid volvulus treated by resection and primary anastomosis: urgent and elective conditions as risk factors for postoperative morbidity and mortality.

Purpose: Sigmoid volvulus is a major cause of intestinal obstruction. The aim of this study is to analyze urgent and elective conditions as risk factors for morbidity and mortality regarding sigmoid colon resection and primary anastomosis in patients with sigmoid volvulus.

Methods: This retrospective study included 63 patients diagnosed with sigmoid volvulus, who underwent sigmoid colon resection plus primary anastomosis under urgent or elective conditions between January 1994 and December 2010.

Selecting a surgical modality to treat a splenic hydatid cyst: total splenectomy or spleen-saving surgery?

Aim: We analyzed the outcomes and effectiveness of surgical treatments and clinical manifestations of splenic hydatid cysts.

Patients And Methods: Between 2000 and 2011, we retrospectively reviewed the cases of 11 patients who were operated on for a splenic hydatid cyst. The demographic features, medical history, physical examinations, biochemical and serological tests, imaging modalities, and surgical treatment of the patients were noted.

Primary echinococcal cyst in the axillary region.

Introduction: Human hydatid disease is a parasitic infection caused by the larval form of Echinococcus granulosus. It has worldwide distribution and is endemic in many countries, especially the Mediterranean region. It most commonly affects the liver and lungs although multi-organ involvement has been observed in 20-30% of patients.

Treatment of Brucella endocarditis: 15 years of clinical and surgical experience.

Background: Brucella endocarditis is a life-threatening complication of human brucellosis. In this study, our aim was to evaluate the effects of combined medical and surgical treatment in the midterm to long term.

Methods: We retrospectively analyzed 13 patients (mean age 44 +/- 18 years; 8 males) who were operated on from January 1993 to June 2009.

Non-traumatic splenic rupture: report of seven cases and review of the literature.

Aim: To evaluate seven patients with non-traumatic splenic rupture (NSR). NSR is an uncommon dramatic abdominal emergency that requires immediate diagnosis and prompt surgical treatment to ensure the patient's survival.

Methods: Within 11 years, seven cases were evaluated for patient characteristics, anamnesis and symptoms, method of diagnosis, findings of laparotomy, and etiology of NSR.

[The evaluation of 250 patients with thoracoabdominal injuries].

Background: Prognostic factors affecting mortality and morbidity in thoracoabdominal injuries were evaluated.

Methods: Two hundred and fifty patients (227 males, 23 females; mean age 30.1+/-5.

Elective shunt use for easy resection of a carotid body tumor.

Carotid body tumor resection has the potential hazards of hemorrhage, cranial nerve palsy, and cerebrovascular accident. The control of intraoperative bleeding during manipulation of the tumor is a critical issue for safe resection. In the presented case with a carotid body tumor, the Shamblin II, a carotid shunt with a dual balloon was used electively.

Surgical treatment of post-infarction left ventricular pseudoaneurysm: a two-decade experience.

Herein, we present a retrospective analysis of our experience with acquired pseudoaneurysms of the left ventricle over a 20-year period.From February 1985 through September 2004, 14 patients underwent operation for left ventricular pseudoaneurysm in our clinic. All pseudoaneurysms (12 chronic, 2 acute) were caused by myocardial infarction.