Publications by authors named "Kelen Klein Heffel"
Safety and efficacy of biologic drugs in children or adolescents with atopic dermatitis: A systematic review and meta-analysis of randomized controlled trials.
Ana Clara Felix de Farias Santos Fernanda Valeriano Zamora Lorhayne Kerly Capuchinho Scalioni Galvao Nicole Dos Santos Pimenta João Pedro Costa Esteves Almuinha Salles Kélen Klein Heffel
Australas J Dermatol
November 2024
Article Synopsis
- * A meta-analysis of five randomized controlled trials found that biologic drugs (dupilumab, lebrikizumab, tralokinumab) significantly improved various measures of AD compared to placebo, including Investigator Global Assessment and Eczema Area and Severity Index scores.
- * The study showed no significant difference in adverse events between biologic treatments and placebo, suggesting that these drugs are both effective and safe for improving outcomes in young patients with AD, although more research is needed.
Corneal crosslinking (CXL) is used for treating keratoconus and post-laser in situ keratomileusis ectasia. However, refractive surgery is not usually performed with prophylactic CXL. Therefore, we performed a meta-analysis comparing outcomes of refractive surgeries with vs without prophylactic CXL.
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