[Biosynthesis and regulatory mechanism of acarbose and its structural analogs: a review].

Acarbose is widely used as α-glucosidase inhibitor in the treatment of type Ⅱ diabetes. sp. is used for industrial production of acarbose.

Gene Cascade Shift and Pathway Enrichment in Rat Kidney Induced by Acarbose Through Comparative Analysis.

Acarbose is an effective anti-diabetic drug to treat type 2 diabetes mellitus (T2DM), a chronic degenerative metabolic disease caused by insulin resistance. The beneficial effects of acarbose on blood sugar control in T2DM patients have been confirmed by many studies. However, the effect of acarbose on patient kidney has yet to be fully elucidated.

Enhancement of gibberellic acid production from by mutation breeding and glycerol addition.

Gibberellic acid (GA) is a natural plant growth hormone that has been widely used in agriculture and horticulture. To obtain higher GA producing strains, the method of screening the strains for resistance to simvastatin was used after treatment with nitrosoguanidine (NTG) and gamma rays. The rationale for the strategy was that mutants showing simvastatin resistance were likely to be high GA producers, as their activity of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is relatively more effective.