Publications by authors named "Kelechi U Ebirim"
Objective: The precise mechanism and determinants of brain tissue pulsations (BTPs) are poorly understood, and the impact of blood pressure (BP) on BTPs is relatively unexplored. This study aimed to explore the relationship between BP parameters (mean arterial pressure [MAP] and pulse pressure [PP]) and BTP amplitude, using a transcranial tissue Doppler prototype.
Methods: A phantom brain model generating arterial-induced BTPs was developed to observe BP changes in the absence of confounding variables and cerebral autoregulation feedback processes.
Article Synopsis
- Hypocapnia, a condition of reduced carbon dioxide levels, impacts cerebral autoregulation and has potential effects on brain tissue pulsations (BTPs), which are linked to how blood flows in the brain.
- A study with 30 healthy volunteers examined changes in BTP amplitude during hyperventilation-induced mild hypocapnia, revealing significant alterations in BTP amplitude during recovery rather than during the phase of hyperventilation.
- The study highlights the need for more research to clarify the relationship between carbon dioxide levels and BTPs and to understand the physiological factors influencing cerebral blood flow.