Publications by authors named "Keldenn Moreno"
Article Synopsis
- - A 7-year-old child developed dengue symptoms after receiving the Qdenga vaccine, with initial tests showing negative results but later confirming a DENV4 infection.
- - Advanced sequencing techniques revealed the presence of viral RNA from both DENV2 and DENV4, identified as strains derived from the vaccine rather than wild-type viruses.
- - This case highlights the importance of accurate diagnostic practices in vaccinated individuals, emphasizing the need for better understanding of vaccine-induced viremia to enhance dengue surveillance and public health strategies.
Article Synopsis
- * An analysis of viral genome sequences combined with epidemiological data revealed that Italy experienced four significant epidemic waves between 2021 and 2023, marked by reduced fatalities and influenced by variants like Alpha, Delta, and Omicron.
- * This study emphasizes the need for adaptable public health strategies and continuous genomic surveillance to effectively track virus evolution and prepare for potential future outbreaks.
Acute febrile illness (AFI) and severe neurological disorders (SNDs) often present diagnostic challenges due to their potential origins from a wide range of infectious agents. Nanopore metagenomics is emerging as a powerful tool for identifying the microorganisms potentially responsible for these undiagnosed clinical cases. In this study, we aim to shed light on the etiological agents underlying AFI and SND cases that conventional diagnostic methods have not been able to fully elucidate.
View Article and Find Full Text PDFArticle Synopsis
- This text indicates a correction has been made to a previously published article.*
- The article in question has the DOI 10.1016/j.lana.2024.100786, which identifies it uniquely in academic databases.*
- Corrections like this typically address errors or omissions in the original publication to clarify the findings or methods used.*
Background: This study focuses on urban arboviruses, specifically dengue (DENV), chikungunya (CHIKV), and Zika (ZIKV), which pose a significant public health challenge in Rio de Janeiro state, Southeast Brazil. In our research, we highlight critical findings on the transmission dynamics of these arboviruses in Rio de Janeiro, identifying distinct patterns of disease spread.
Methods: By combining genomic data with case reports from the Brazilian Ministry of Health, we have analysed the phylogenetics, prevalence and spatial distribution of these endemic viruses within the state.
Dengue fever is among the most significant public health concerns in Brazil. To date, the highest number of Dengue notifications in the Americas has been reported in Brazil, with cases accounting for a total number of 3,418,796 reported cases as of mid-December 2022. Furthermore, the northeastern region of Brazil registered the second-highest incidence of Dengue fever in 2022.
View Article and Find Full Text PDFThe COVID-19 pandemic has brought significant challenges for genomic surveillance strategies in public health systems worldwide. During the past thirty-four months, many countries faced several epidemic waves of SARS-CoV-2 infections, driven mainly by the emergence and spread of novel variants. In that line, genomic surveillance has been a crucial toolkit to study the real-time SARS-CoV-2 evolution, for the assessment and optimization of novel diagnostic assays, and to improve the efficacy of existing vaccines.
View Article and Find Full Text PDF