Publications by authors named "Kelaiah Reffell"
Loss of G0/G1 switch gene 2 (G0S2) promotes disease progression and drug resistance in chronic myeloid leukaemia (CML) by disrupting glycerophospholipid metabolism.
Mayra A Gonzalez Idaly M Olivas Alfonso E Bencomo-Alvarez Andres J Rubio Christian Barreto-Vargas Kelaiah Reffell
Clin Transl Med
December 2022
Article Synopsis
- Tyrosine kinase inhibitors (TKIs) have transformed chronic myeloid leukaemia (CML) from a deadly condition into a manageable one, but drug-resistant leukaemia stem cells present a significant challenge for achieving a cure.
- A new study highlights the downregulation of the G0/G1 switch gene 2 (G0S2), a key regulator of lipid metabolism, in various instances of TKI resistance, which correlates with poorer survival outcomes for patients.
- The research indicates that the decrease in G0S2 is influenced by transcriptional repression from MYC rather than by genetic changes or BCR::ABL1 activity, suggesting that restoring G0S2 could be crucial for improving treatment responses