A pan-cancer analysis reveals the oncogenic and immunological role of insulin-like growth factor 2 mRNA-binding protein family members.

Purpose: To investigate the expression and clinical significance of insulin-like growth factor 2 mRNA-binding protein family members (IGF2BPs) in pan-cancer and evaluate their potential as targets for tumor immunotherapy.

Methods: Based on data from the cancer genome atlas (TCGA) database, pan-cancer analysis was conducted to examine the clinical significance of IGF2BPs expression in twenty-two tumors.

Results: Differential expression analysis showed high expression of IGF2BPs in most tumor tissues.

Microstructure and properties of electroless Ni-P/Sn2.5Ag0.7Cu0.1RE micro-joints during thermomigration.

The Ni-P stratum was fabricated upon the Cu substrate via an electroless plating technique, and the microstructure and properties of electroless Ni-P/Sn2.5Ag0.7Cu0.

Characteristics of the Corneal Endothelium in Elderly Adults with High Myopia.

This cross-sectional study aimed to investigate the corneal endothelial characteristics in elderly individuals with high myopia. We assessed corneal endothelial characteristics in 1065 eyes of 1065 elderly patients (549 highly myopic and 516 control eyes) using non-contact specular microscopy. Confirmation of suspected Fuchs endothelial corneal dystrophy (FECD) was performed with slit-lamp and confocal microscopy.

Exploring the Effect of Nanopore Microstructures on Crystallization and the Evolution of Molecular Assembly Structure by F Solid-State Nuclear Magnetic Resonance Spectroscopy.

The pore microstructure of mesoporous materials has a vital influence on molecular movement and assembly as well as crystallization. Nonetheless, previous studies have predominantly concentrated on the impact of pore size and pore shape on molecular assembly and nucleation outcomes; investigations delving into the effects of more complex pore structures on molecular assembly and nucleation behaviors were absent. In this study, evolution of the molecular self-assembly process of flufenamic acid (FFA) confined in mesoporous materials with different microstructures was monitored by in situ F solid-state NMR spectroscopy.

Synergistic photothermal and chemo-therapeutic platform utilizing CuSe/PDA/AIPH nanoparticles for targeted tumor eradication.

In this study, we developed an innovative CuSe/PDA/AIPH nanoparticle platform that combines photothermal therapy and chemotherapy for effective tumor treatment. The CuSe nanoparticles, known for their strong near-infrared (NIR) absorption, were encapsulated within a polydopamine (PDA) and 2,2'-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride (AIPH) matrix. Upon NIR irradiation, the platform triggers localized heating and subsequent thermal decomposition of AIPH, releasing ROS to induce significant oxidative damage in tumor cells.

[Cloning and application in synthetic biology of chalcone synthase gene from Lithocarpus litseifolius].

Lithocarpus litseifolius is rich in the chalcones phloridzin and trilobatin, the biosynthesis pathways of which have not been fully demonstrated. Chalcone synthase(CHS) is the first key rate-limiting enzyme in the biosynthesis of flavonoids in plants. To explore the functions of CHS gene family in chalcone synthesis of L.

A Pyrroloquinazoline Analogue Regulated Streptococcus mutans and Streptococcus sanguinis Dual-Species Biofilms.

Objective: Selective inhibition of cariogenic bacteria is regarded as a potential strategy against caries. To assess the potential of SCH-79797, one novel promising antibiotic, in microbial equilibrium using a dual-species biofilms model of Streptococcus mutans (S. mutans) and Streptococcus sanguinis (S.

Erratum: Octopod PtCu Nanoframe for Dual-Modal Imaging-Guided Synergistic Photothermal Radiotherapy: Erratum.

[This corrects the article DOI: 10.7150/thno.22557.

Metabolic Dysfunction-associated Steatotic Liver Disease Increases the Risk of Primary Open-Angle Glaucoma.

Purpose: Liver disease is associated with a range of extrahepatic complications, which have recently been expanded to include ophthalmic conditions. However, evidence is lacking regarding its impact on primary open-angle glaucoma (POAG). This study aimed to investigate whether major liver diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD), alcoholic liver disease (ALD), viral hepatitis, and liver fibrosis and cirrhosis, were associated with POAG.

Structural basis of the bifunctionality of Marinobacter salinexigens ZYF650 glucosylglycerol phosphorylase in glucosylglycerol catabolism.

2-O-α-Glucosylglycerol (GG) is a natural heteroside synthesized by many cyanobacteria and a few heterotrophic bacteria under salt stress conditions. Bacteria produce GG in response to stimuli and degrade it once the stimulus diminishes. Heterotrophic bacteria utilize GG phosphorylase (GGP), a member of the GH13_18 family, via a two-step process consisting of phosphorolysis and hydrolysis for GG catabolism.

Interfacial modulation of hierarchically porous UIO-66 for the immobilization of Rhizomucor miehei lipase towards the efficient synthesis of 1,3-dioleic acid glycerol.

Herein, UiO-66 was selected as the immobilization carrier of Rhizomucor miehei lipase (RML). After etching and hydrophobic modification, the functionalized UIO-66 (H-UIO-66-OPA) was utilized for RML immobilization and the obtained RML@H-UIO-66-OPA showed about 70 % relative activity after incubation at 60 °C, which was much better than RML (20 %). RML@H-UIO-66-OPA was used in the synthesis of 1,3-dioleic acid glycerol (1,3-DAG) and the effects of reaction conditions (temperature, enzyme addition, substrate molar ratio, and time) on 1,3-DAG yield were investigated.

Engineering fluorene-based covalent organic framework photocatalysts toward efficient and selective aerobic oxidation of amines.

Covalent organic frameworks (COFs) have attracted significant interest due to diverse applications, relying on their versatile molecular building blocks like fluorenes. However, the twisted structures of fluorenes pose substantial challenges for the construction of porous crystalline materials like COFs. Here, the couplings of 1,3,5-triformylphloroglucinol (Tp) with 9H-fluorene-2,7-diamine (DAF), 9,9-dimethyl-9H-fluorene-2,7-diamine (MFC) and 9,9-difluoro-9H-fluorene-2,7-diamine (FFC) with a pyrrolidine catalyst afford three fluorene-based COFs, TpDAF-COF, TpMFC-COF and TpFFC-COF, respectively.

Myofibroblast-derived extracellular vesicles facilitate cancer stemness of hepatocellular carcinoma via transferring ITGA5 to tumor cells.

Background: Myofibroblasts constitute a significant component of the tumor microenvironment (TME) and play a pivotal role in the progression of hepatocellular carcinoma (HCC). Integrin α5 (ITGA5) is a crucial regulator in myofibroblasts of malignant tumors. Therefore, the potential of ITGA5 as a novel target for the therapeutic strategy of HCC should be investigated.

Zirconium metal-organic framework photocatalysis with TEMPO for blue light-powered aerobic sulfoxidation.

A zirconium metal-organic framework (MOF), NU-1003, along with TEMPO (2,2,6,6-tetramethylpiperidine--oxyl), is constructed as a system of cooperative photocatalysis for blue light-powered aerobic sulfoxidation. The incorporation of 4 mol% of TEMPO enhances the hole transfer and thereby aerobic sulfoxidation by NU-1003 photocatalysis, demonstrating the pivotal role of a redox mediator in transforming an established MOF.

Solid Forms of Bio-Based Monomer Salts for Polyamide 512 and Their Effect on Polymer Properties.

Polyamides' properties are greatly influenced by the polymerization process and the type of feedstock used. The solid forms of nylon salts play a significant role in determining the final characteristics of the material. This study focuses on the long-chain bio-nylon 512.

Effectiveness of prophylactic capsular tension ring implantation during cataract surgery in highly myopic eyes.

Purpose: To assess the effectiveness of prophylactic capsular tension ring (CTR) implantation during cataract surgery in highly myopic eyes.

Setting: Eye and Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.

Design: Prospective cohort study.

Orientation-Dependent Photocatalysis of Imine-Linked Covalent Organic Frameworks Based on Thienothiophenes for Oxidation of Amines to Imines.

Toward visible light photocatalysis, covalent organic frameworks (COFs) have recently garnered growing attention. The effect of different orientations of imine of imine-linked COFs on photocatalysis should be elucidated. Here, two COFs are developed with 2,5-diphenylthieno[3,2-]thiophene (DPTT) and 1,3,6,8-tetraphenylpyrene (Py) linked by imine, affording DPTT-Py-COF and Py-DPTT-COF, respectively.

Morphologic features of iris in highly myopic eyes based on a novel swept-source optical coherence tomography.

Background: To investigate the morphologic features of iris in the highly myopic (HM) eyes using a novel swept-source optical coherence tomography (SS-OCT).

Methods: In this retrospective case-control study, 100 eyes of 100 patients scheduled to have cataract surgery were included, categorized into the control (22 mm< AL < 24.5 mm) and HM (AL ≥ 26 mm) groups.

A Novel Artificial Intelligence-Based Classification of Highly Myopic Eyes Based on Visual Function and Fundus Features.

Purpose: To develop a novel classification of highly myopic eyes using artificial intelligence (AI) and investigate its relationship with contrast sensitivity function (CSF) and fundus features.

Methods: We enrolled 616 highly myopic eyes of 616 patients. CSF was measured using the quantitative CSF method.

Endothelial α-adrenergic receptor activation improves cardiac function in septic mice via PKC-ERK/p38MAPK signaling pathway.

Cardiomyopathy is particularly common in septic patients. Our previous studies have shown that activation of the alpha 1 adrenergic receptor (α-AR) on cardiomyocytes inhibits sepsis-induced myocardial dysfunction. However, the role of cardiac endothelial α-AR in septic cardiomyopathy has not been determined.

Unlocking the potential of stimuli-responsive biomaterials for bone regeneration.

Bone defects caused by tumors, osteoarthritis, and osteoporosis attract great attention. Because of outstanding biocompatibility, osteogenesis promotion, and less secondary infection incidence ratio, stimuli-responsive biomaterials are increasingly used to manage this issue. These biomaterials respond to certain stimuli, changing their mechanical properties, shape, or drug release rate accordingly.

Fluoride-resistant within cross-kingdom biofilms support growth under fluoride and attenuate the anti-caries effect of fluorine.

Fluoride-resistant () might affect the ecological balance of biofilms in the presence of fluoride. We used a and () cross-kingdom biofilm model to investigate whether fluoride-resistant in biofilms would support growth under fluoride stress and attenuate the anti-caries effect of fluorine. The impact of fluoride-resistant on formation of cross-kingdom biofilms by and in the presence of fluoride was investigated using the crystal violet staining assay.

Effect of electromigration on microstructure and properties of CeO nanopartical-reinforced Sn58Bi/Cu solder joints.

To mitigate the decrease in mechanical performance of Sn58Bi/Cu solder joints resulting from electromigration-induced damage. The CeO nanoparticles were incorporated into Sn58Bi solder by a melt-casting method, and their effects on the microstructure and properties of Sn58Bi/Cu solder joints under electromigration were investigated. The study results demonstrate that the addition of 0.

Structural insight into the functional regulation of Elongation factor Tu by reactive oxygen species in Synechococcus elongatus PCC 7942.

In cyanobacteria, Elongation factor Tu (EF-Tu) plays a crucial role in the repair of photosystem II (PSII), which is highly susceptible to oxidative stress induced by light exposure and regulated by reactive oxygen species (ROS). However, the specific molecular mechanism governing the functional regulation of EF-Tu by ROS remains unclear. Previous research has shown that a mutated EF-Tu, where C82 is substituted with a Ser residue, can alleviate photoinhibition, highlighting the important role of C82 in EF-Tu photosensitivity.

Habitual coffee and tea consumption and risk of cataract: A prospective cohort study from the UK Biobank.

Background: To study the association of habitual coffee and tea consumption with the risk of cataract.

Methods: This prospective cohort study enrolled UK Biobank participants between 2006 and 2010, and prospectively followed them up for cataract diagnosis. We examined the associations of self-reported intake of tea and coffee and the calculated combined caffeine intake, with the risk of incident cataract.