Unveiling the Connection Between Micronutrients and Autoimmune Thyroiditis: Are They True Friends?

The role of micronutrients in autoimmune thyroiditis (AIT) has been controversial and lacks sufficient genetic evidence. This study aimed to assess the relationships between various micronutrients and AIT by Mendelian randomization (MR). The single nucleotide polymorphisms (SNPs) of micronutrients and AIT were acquired from IEU Open GWAS project and FinnGen, and were screened according to the basic assumptions of MR.

Causal effects of various particulate matter on inflammatory bowel disease and its subtypes: insights from Mendelian randomization.

The role of particulate matter (PM) on genetic susceptibility to inflammatory bowel disease (IBD) is a controversial topic. The study aims to evaluate the causal effect of PM on IBD using Mendelian randomization (MR). PM and IBD datasets were screened for common single nucleotide polymorphisms (SNPs) based on the MR basic assumptions.

Unequal causality between autoimmune thyroiditis and inflammatory bowel disease: a Mendelian randomization study.

Objective: This study aims to analyze the causal relationship between autoimmune thyroiditis (AIT) and inflammatory bowel disease (IBD) using bidirectional Mendelian randomization (MR).

Methods: Single nucleotide polymorphisms were obtained from FinnGen. Exposure-outcome causality was assessed using inverse variance weighted, MR-Egger, and weighted median.

Effect of post-traumatic stress disorder on type 2 diabetes and the mediated effect of obesity: a Mendelian randomization study.

Objective: Whether the role of post-traumatic stress disorder (PTSD) on type 2 diabetes (T2D) is mediated by obesity or other mediating factors is controversial. This study was designed to assess the impact of PTSD on genetic susceptibility to T2D and mediating factors.

Methods: The datasets for PTSD, T2D, obesity, hypertension, hyperlipidemia, smoking status, and alcohol consumption were obtained from genome-wide association studies.

Risk cycling in diabetes and autism spectrum disorder: a bidirectional Mendelian randomization study.

Objective: The relationship between diabetes mellitus (DM) and autism spectrum disorder (ASD) remains controversial. This study aimed to analyze the causal relationship between different types of DM and ASD by bidirectional Mendelian randomization (MR).

Methods: Single nucleotide polymorphisms for type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), gestational diabetes mellitus (GDM), and ASD were obtained from genome-wide association studies.

Does type 1 diabetes serve as a protective factor against inflammatory bowel disease: A Mendelian randomization study.

Background: The impact of type 1 diabetes (T1D) on inflammatory bowel disease (IBD) remains unclear.

Aim: To analyze the causal relationship between T1D and IBD using Mendelian ran-domization (MR).

Methods: Single nucleotide polymorphisms were sourced from FinnGen for T1D, IBD, ulcerative colitis (UC) and Crohn's disease (CD).

Efficacy and safety of Xileisan combined with mesalazine for ulcerative colitis: A meta-analysis and trial sequential analysis.

Background: The benefits and risks of Xileisan (XLS) in the treatment of ulcerative colitis (UC) remain unclear.

Aim: The present study aimed to evaluate the efficacy and safety of the combination of XLS and mesalazine when treating UC.

Methods: We searched eight databases for clinical trials evaluating the combination of XLS and mesalazine in the treatment of UC, up to January 2024.

Efficacy and safety of esketamine for pediatric gastrointestinal endoscopy: a meta-analysis and trial sequential analysis.

Objective: The role of esketamine in pediatric gastrointestinal endoscopy is still unclear. This study aims to evaluate the efficacy and safety of esketamine for pediatric gastrointestinal endoscopy.

Methods: Clinical trials of esketamine for pediatric gastrointestinal endoscopy were searched in eight common databases, up to October 2023.

A strategic study of acupuncture for diabetic kidney disease based on meta-analysis and data mining.

Objective: The specific benefit and selection of acupoints in acupuncture for diabetic kidney disease (DKD) remains controversial. This study aims to explore the specific benefits and acupoints selection of acupuncture for DKD through meta-analysis and data mining.

Methods: Clinical trials of acupuncture for DKD were searched in eight common databases.

Effect of viral hepatitis on type 2 diabetes: A Mendelian randomization study.

Background: The effects of viral hepatitis (VH) on type 2 diabetes (T2D) remain controversial.

Aim: To analyze the causal correlation between different types of VH and T2D using Mendelian randomization (MR).

Methods: Single nucleotide polymorphisms of VH, chronic hepatitis B (CHB), chronic hepatitis C (CHC) and T2D were obtained from the BioBank Japan Project, European Bioinformatics Institute, and FinnGen.

Effect of tea intake on genetic predisposition to gout and uric acid: a Mendelian randomization study.

Objective: The effect of tea on gout and uric acid is still controversial. This study aims to analyze the effect of tea intake on genetic predisposition to gout, idiopathic gout, gout due to impairment of renal function as well as uric acid by Mendelian randomization (MR).

Methods: Forty independent single nucleotide polymorphisms (SNPs) associated with tea intake were selected from UK Biobank.

Research status and hotspots of autoimmune gastritis: A bibliometric analysis.

Background: As an emerging potential risk factor for gastric cancer, autoimmune gastritis (AIG) has garnered increasing attention from researchers.

Aim: To analyze the research overview and popular topics in the field of AIG using bibliometrics.

Methods: Relevant publications on AIG in the Web of Science Core Collection were collated, and data visualization and analysis of the number of publications, countries, institutions, journals, authors, keywords, and citations were performed using software such as VOSviewer, CiteSpace, and Scimago Graphic.

Is acupoint injection the optimal way to administer mecobalamin for diabetic peripheral neuropathy? A meta-analysis and trial sequential analysis.

Objective: Mecobalamin is a commonly used drug in the treatment of diabetic peripheral neuropathy (DPN). This study aimed to systematically evaluate the efficacy and safety of acupoint injection of mecobalamin for DPN.

Methods: Relevant clinical trials on acupoint injection of mecobalamin for DPN published before 31 January 2023 were searched in eight commonly used databases.

Gastrointestinal adverse events of tirzepatide in the treatment of type 2 diabetes mellitus: A meta-analysis and trials sequential analysis.

Background: Tirzepatide (TZP) is a novel drug for type 2 diabetes mellitus (T2DM), but the gastrointestinal (GI) adverse events (AEs) is a limiting factor in clinical application. Therefore, this study systematically evaluated the GI AEs of TZP for T2DM.

Methods: Clinical trials of TZP for T2DM were retrieved from eight databases published only from the establishment of the database to February 2023.

Influence of TiN Inclusions and Segregation Bands on the Mechanical Properties and Delayed Crack in Thick NM550 Wear-Resistant Steel.

The formation mechanism of the delayed crack after flame cutting and mechanical properties in thick NM550 wear-resistant steel are studied by optical microscopy, scanning electron microscopy, energy dispersive spectroscopy, X-ray diffraction, and an electron backscattered diffractometer. The delayed crack is formed at the segregation zone (SZ) located in the center of the 65 mm thick steel plate. The strength of the non-segregation zone (NSZ) with a martensite microstructure is slightly higher than that of SZ with a mixture microstructure of martensite plus bainite, and the plasticity of NSZ is significantly better than that of SZ.

Efficacy and safety of dorzagliatin for type 2 diabetes mellitus: A meta-analysis and trial sequential analysis.

Objective: To evaluate the efficacy and safety of dorzagliatin in the treatment of type 2 diabetes mellitus (T2DM) by using meta-analysis and trial sequential analysis (TSA).

Method: Search for clinical trials of dorzagliatin for T2DM in eight databases, with a time limit of build to July 2022. The included studies that met the requirements were carried out for meta-analysis and TSA.