DOT1L regulates cellular senescence during the progression from acute kidney injury to chronic kidney disease via the micro-222-5p/WNT9B signaling pathway.

Background: Acute kidney injury (AKI) is a common clinical condition where cellular senescence plays a crucial role in its progression. Previous studies have suggested that DOT1L plays a pivotal role in cellular senescence, yet its specific mechanisms in regulating AKI cellular senescence remain unclear.

Methods: This study utilized a glycerol-induced in vivo AKI model and employed the DOT1L-specific inhibitor EPZ004777 (EPZ) to suppress DOT1L function.

Identification and Application of the Heptad Repeat Domain in the CPR5 Protein for Enhancing Plant Immunity.

Plant resistance to pathogens can be significantly enhanced through genetic modification, thereby reducing the reliance on chemical pesticides. CONSTITUTIVE EXPRESSER OF PATHOGENESIS-RELATED GENES 5 (CPR5) serves as a key negative regulator of plant immunity. Here we explored the functional domains of the CPR5 protein with the goal of dampening its activity to bolster plant immunity.

A case report of gastric antral vascular ectasia treated by endoscopic band ligation combined with lauromacrogol injection.

Rationale: Gastric antral vascular ectasia (GAVE) is a rare acquired lesion characterized by vascular dilation in the gastric antrum, frequently results in occult or overt gastrointestinal bleeding. Endoscopic intervention remains the cornerstone of therapy. Argon plasma coagulation was previously considered a first treatment option.

Research on the impact of county urbanization in Jiangxi Province on carbon budget balance.

Investigating the effects of urbanization at the county level on the balance of the carbon budget is essential for progress toward achieving "dual carbon" objectives at the county scale. Based on land use and economic data, this study elucidates the spatiotemporal evolution of urbanization and carbon budget balance ratio in 84 counties in Jiangxi Province from 1980 to 2020. Optimal geographic detectors and geographically weighted random forests were used to explore the impact of urbanization on the carbon budget balance ratio.

Mitochondrial dysfunction in acute kidney injury.

Acute kidney injury (AKI) is a systemic clinical syndrome increasing morbidity and mortality worldwide in recent years. Renal tubular epithelial cells (TECs) death caused by mitochondrial dysfunction is one of the pathogeneses. The imbalance of mitochondrial quality control is the main cause of mitochondrial dysfunction.

Poly (ADP-ribose) polymerase 1 promotes HuR/ELAVL1 cytoplasmic localization and inflammatory gene expression by regulating p38 MAPK activity.

Post-transcriptional regulation of cytokine/chemokine mRNA turnover is critical for immune processes and contributes to the mammalian cellular response to diverse inflammatory stimuli. The ubiquitous RNA-binding protein human antigen R (HuR) is an integral regulator of inflammation-associated mRNA fate. HuR function is regulated by various post-translational modifications that alter its subcellular localization and ability to stabilize target mRNAs.

Iron-modified biochar effectively mitigates arsenic-cadmium pollution in paddy fields: A meta-analysis.

The escalating problem of compound arsenic (As) and cadmium (Cd) contamination in agricultural soils necessitates the urgency for effective remediation strategies. This is compounded by the opposing geochemical behaviors of As and Cd in soil, and the efficacy of biochar treatment remains unclear. This pioneering study integrated 3780 observation pairs referred from 92 peer-reviewed articles to investigate the impact of iron-modified biochar on As and Cd responses across diverse soil environments.

Clinical and Epidemiological Characteristics of Rhabdomyolysis: A Retrospective Study.

Background: Rhabdomyolysis (RM) refers to a clinical syndrome in which muscle cells are damaged by various causes and the clinical manifestations are mainly muscle pain, weakness, and dark urine. Acute kidney injury (AKI) is a serious complication of RM with complex mechanisms and high mortality. Therefore, understanding the pathogenesis and clinical manifestations, early diagnosis and treatment of RM are crucial to improve its prognosis.

The roles of interleukin-17A in risk stratification and prognosis of patients with sepsis-associated acute kidney injury.

Background: The aim of this study was to evaluate the roles of interleukin (IL)-17A in risk stratification and prognosis of patients with sepsis-associated acute kidney injury (SAKI).

Methods: We enrolled 146 sepsis patients (84 non-SAKI and 62 SAKI patients) admitted to the emergency department from November 2020 to November 2021. Patients with SAKI were differentiated based on the severity of acute kidney injury.

Volume Deformation and Hydration Behavior of Ordinary Portland Cement/Calcium Sulfoaluminate Cement Blends.

Blends of ordinary Portland cement (OPC) and calcium sulfoaluminate (CSA) cement can be used to adjust the properties of cement for specific applications. In this study, CSA cement was used as a shrinkage-compensating admixture to improve the hydration behavior and performance (compressive strength and drying shrinkage) of OPC; the expansion behavior of the blended cement mortar was evaluate based on the saturation index of ettringite. The experimental results showed that incorporating CSA cement resulted in a delayed effect on the hydration of CS, shortened the induction periods of the blended cement and decreased the setting time.

Effect of air pollution-controlled residue of a sewage sludge incinerator on the drying shrinkage and the pore structure of alkali-activated materials.

Recycling air pollution-controlled residues (APCR) generated from sewage sludge incinerators can be used for waste management, but the leaching of potentially toxic heavy metals from APCR poses environmental and human health issues. The present paper describes a procedure using APCR to produce alkali-activated materials and thereby realize their disposal. The effect of APCR on the compressive strength and drying shrinkage of the alkali-activated slag/glass powder was investigated.

Improved 2α-Hydroxylation Efficiency of Steroids by CYP154C2 Using Structure-Guided Rational Design.

Cytochrome P450 enzymes are promising biocatalysts for industrial use because they catalyze site-selective C-H oxidation and have diverse catalytic reactions and a broad substrate range. In this study, the 2α-hydroxylation activity of CYP154C2 from Streptomyces avermitilis MA-4680T toward androstenedione (ASD) was identified by an conversion assay. The testosterone (TES)-bound structure of CYP154C2 was solved at 1.

Multiobjective path optimization of an indoor AGV based on an improved ACO-DWA.

With their intelligence, flexibility, and other characteristics, automated guided vehicles (AGVs) have been popularized and promoted in traditional industrial markets and service industry markets. Compared with traditional transportation methods, AGVs can effectively reduce costs and improve the efficiency of problem solving in various application developments, but they also lead to serious path-planning problems. Especially in large-scale and complex map environments, it is difficult for a single algorithm to plan high-quality moving paths for AGVs, and the algorithm solution efficiency is constrained.

Advances in the use of recycled non-ferrous slag as a resource for non-ferrous metal mine site remediation.

The growing global demand for non-ferrous metals has led to serious environmental issues involving uncovered mine site slag dumps that threaten the surrounding soils, surface waters, groundwater, and the atmosphere. Remediation of these slags using substitute cement materials for ordinary Portland cement (OPC) and precursors for alkali-activated materials (AAMs) can convert hazardous solid wastes into valuable construction materials, as well as to attain the desired solidification and stabilization (S/S) of heavy metal(loid)s (HM). This review discusses the current research on the effect of non-ferrous slags on the reaction mechanisms of the OPC and AAM.

Transcutaneous Electrical Acustimulation Improved the Quality of Life in Patients With Diarrhea-Irritable Bowel Syndrome.

Background And Aim: Patients with diarrhea-dominant irritable bowel syndrome (IBS-D) experience abdominal pain and reduced quality of life and need effective treatments. This study aimed to evaluate whether transcutaneous electrical acustimulation (TEA) at two acupuncture points, LI4 and ST36, could improve pain and quality of life of patients with IBS-D.

Materials And Methods: A total of 42 patients with IBS-D who met the Rome IV criteria were randomly divided into two groups: TEA and sham-TEA.

Exosomal circular RNAs: A new frontier in the metastasis of digestive system tumors.

Exosomes are membrane vesicles with a diameter of 30-150 nm. Exosomes are secreted by various types of tumor cell and contain a variety of proteins, circular RNAs (circRNAs), microRNAs and DNA, depending on the host cells. Among them, circRNAs, which are long non-coding endogenous RNAs, form covalently closed and continuous loops that link the 3' and 5' terminals generated by back-splicing.

The Regime of Rural Ecotourism Stakeholders in Poverty-Stricken Areas of China: Implications for Rural Revitalization.

The rural ecotourism system can be defined as a complex association of stakeholders. This system of rural ecotourism in relatively poor areas of China can influence rural revitalization strategies. The purpose of this study is to plan a rural ecotourism system among the tourism enterprises, local residents and government by using an evolutionary game theory.

Quantitative Evaluation of Carbon Fiber Dispersion in Amorphous Calcium Silicate Hydrate-Based Contact-Hardening Composites.

Carbon fiber dispersion has a substantial influence on the properties of amorphous calcium silicate hydrate-based contact-hardening composites. In this study, a mixture of carbon fiber and calcium silicate hydrate powder was compressed into solid composites at 40 MPa for one minute. The mechanical properties and electrical resistivity of the solid materials were measured, and the dispersion of carbon fibers was quantitatively evaluated by digital image processing technology.

Functional Characterization of Chemosensory Protein AmalCSP5 From Apple Buprestid Beetle, Agrilus mali (Coleoptera: Buprestidae).

In the sensitive and complex chemo-sensation system of insects, chemosensory proteins (CSPs) can facilitate the transfer of chemical information and play important roles for variable behaviors of insects. We cloned the chemosensory protein AmalCSP5 from antennae of the apple buprestid beetle (Agrilus mali Matsumura), a serious invasive pest of wild apple trees. Expression profiling showed that AmalCSP5 was expressed in various tissues, suggesting its significance in multiple physiological activities and behaviors of A.

Setting and Hardening Behaviour of Alkali-Activated Landfilled Fly Ash-Slag Binder at Room Temperature.

A geopolymer is normally considered an environmentally friendly binder due to the utilisation of industrial wastes. This study focusses on the potential of geopolymer preparation at room temperature from landfilled fly ash (LFA) which has been discharged to the land for more than three years. To accelerate the reaction process, 20-30 wt.

Hydrogen Sulfide Maintained the Good Appearance and Nutrition in Post-harvest Tomato Fruits by Antagonizing the Effect of Ethylene.

Hydrogen sulfide (HS) could act as a versatile signaling molecule in delaying fruit ripening and senescence. Ethylene (CH) also plays a key role in climacteric fruit ripening, but little attention has been given to its interaction with HS in modulating fruit ripening and senescence. To study the role of HS treatment on the fruit quality and nutrient metabolism, tomato fruits at white mature stage were treated with ethylene and ethylene plus HS.

Identification of biomarkers associated with diagnosis and prognosis of colorectal cancer patients based on integrated bioinformatics analysis.

Background: The current study aimed to identify potential diagnostic and prognostic gene biomarkers for colorectal cancer (CRC) based on the Gene Expression Omnibus (GEO) datasets and The Cancer Genome Atlas (TCGA) dataset.

Methods: Microarray data of gene expression profiles of CRC from GEO and RNA-sequencing dataset of CRC from TCGA were downloaded. After screening overlapping differentially expressed genes (DEGs) by R software, functional enrichment analyses of the DEGs were performed using the DAVID database.