Superselective embolic particle guidance in vessel networks via shape-adaptive acoustic manipulation.

Interventional embolization has been widely used as a clinical cancer therapy, which deactivates the tumors by occluding their blood supply vessels. However, conventional methods lack active control over the embolic particles, thus having a limited selectivity of millimeter-scale vessels and the issue of missing embolization. Here, we propose an ultrasound-based method for embolic particle control in submillimeter vessels.

Prevalence, Patterns, and Nomogram Model of Intimate Partner Violence Against Mothers During the Child-Rearing Stage: A Family System Analysis in China for Targeted Prevention Strategies.

Intimate partner violence (IPV) is a significant public health issue affecting many women worldwide. While extensive research exists on IPV during pregnancy and postpartum, there is limited information on IPV against mothers during the critical child-rearing stage, specifically the first three years following childbirth. This study examines the prevalence and patterns of IPV among mothers in China during this stage, identifying associated factors across four family subsystems: individual, husband-and-wife, mother-child, and family context, to guide the development of tailored prevention strategies.

Beta oscillation modulations of the orienting attention network effect correlate with dopamine-dependent motor symptoms of Parkinson's disease.

Attention impairment, a prevalent non-motor symptom in Parkinson's disease (PD), plays a crucial role in movement disorders. PD patients exhibit abnormalities in the attentional network related to alerting, orienting, and executive control. While dopamine medications have well-documented effects on motor function, their impact on attention networks and the underlying neural mechanisms involved in motor functions remain unclear.

Clinical and Multimodal Imaging Features of Hepatic Inflammatory Pseudotumors: A Two-Center Retrospective Study.

Objectives: Current literature on imaging characteristics of hepatic inflammatory pseudotumor (HIPT) is limited. This study aimed to analyze the contrast-enhanced ultrasound (CEUS) features in HIPT and compare them with contrast-enhanced computed tomography (CECT) and contrast-enhanced magnetic resonance imaging (CEMRI).

Methods: A total of 83 patients with histologically proven HIPT from two medical institutions were included in this study.

Enhancement of far-infrared laser damage threshold in Ge-As-Se glass fiber.

The application of As-Se chalcogenide glasses in high-power laser delivery is hindered by their low damage threshold due to their weak chemical bonds. To solve this, we introduced germanium elements into the As-Se glasses and optimized the composition to raise the glass transition temperature (T) and enhance the laser damage threshold (LDT). From the correlation among various parameters including T, LDT, and fiber loss, we concluded an optimized composition of GeAsSe/GeAsSe glass.

Rehabilitation Response in Tremor- and Non-Tremor-Dominant Parkinson Disease: A Task-fMRI Study.

Background: Tremor-dominant (TD) and nontremor-dominant (NTD) Parkinson's disease (PD) showed different responses to rehabilitation. However, the neural mechanism behind this remains unclear.

Methods: This cohort study explores changes in motor function, brain activation, and functional connectivity following 2 weeks of rehabilitation in TD-PD and NTD-PD patients, respectively.

HAND2-AS1 plays a tumor-suppressive role in hepatoblastoma through the negative regulation of CDK1.

Objective: Hepatoblastoma (HB) is the most commonly seen pediatric liver malignancy. The preliminary experiment of our research group found that cyclin dependent kinase 1 (CDK1) was upregulated in HB. By in silico analysis, long noncoding RNA (lncRNA) HAND2 antisense RNA 1 (HAND2-AS1) was determined as the research object.

Coarse-Fine Nested Network for Weakly Supervised Group Activity Recognition.

Weakly supervised group activity recognition (WSGAR) aims at identifying the overall behavior of multiple persons without any fine-grained supervision information (including individual position and action label). Traditional methods usually adopt a person-to-whole way: detect persons via off-the-shelf detectors, obtain person-level features, and integrate into the group-level features for training the classifier. However, these methods are unflexible due to serious reliance on the quality of detectors.

Uniform Graft-versus-Host Disease Prophylaxis using Post-Transplantation Cyclophosphamide, Methotrexate, and Cyclosporine following Peripheral Blood Hematopoietic Stem Cell Transplantation from Matched and Haploidentical Donors for Transfusion-Dependent Thalassemia: A Retrospective Report from the Bone Marrow Failure Working Group of Hunan Province, China.

Although the survival of patients with transfusion-dependent thalassemia (TD-TM) is reportedly inferior after haploidentical hematopoietic stem cell transplantation (HSCT), the heterogeneity of transplantation approaches in studies suggests the need to assess the effect of conditioning regimen on matched and haploidentical transplantation outcomes. A novel post-transplantation cyclophosphamide (PTCy)-based approach for patients with TD-TM undergoing haploidentical HSCT was reported in our prior study. Here we aimed to retrospectively evaluate the real-world efficacy and safety of graft-versus-host disease (GVHD) prophylaxis in patients with TD-TM after HSCT from matched donors and haploidentical donors (HIDs).

Identification of Pathogen Causing Bulb Rot in P. Y. Li and Establishment of Detection Methods.

P. Y. Li () is a traditional Chinese herbal medicine that has been used for over two millennia to treat cough and expectoration.

Massive fabrication of functional hepatic cancer spheroids by micropatterned GelMA hydrogel chip for drug screening.

Since hepatic cancer incidence and mortality continue to grow worldwide, it is necessary to develop the biomimetic tumor models for drug development and tumor therapeutics. Cellular spheroids as an excellent simple 3D model can bridge the gap between 2D cell culture and live tissue. In this study, we proposed a biological methacrylated gelatin (GelMA) hydrogel-based microplatform for the massive generation of hepatocellular spheroids and downstream investigation of drug resistance.

Visible-Light-Induced Silk Fibroin Hydrogels with Carbon Quantum Dots as Initiators for 3D Bioprinting Applications.

Digital light processing (DLP) 3D bioprinting technology has attracted increasing attention in tissue engineering in recent years. However, it still faces significant technical and operational challenges such as cell carcinogenesis caused by prolonged exposure to ultraviolet light and the presence of heavy metal ions in complex photoinitiator systems. In this study, a novel strategy is designed to introduce carbon quantum dots into visible-light-induced silk fibroin bioink as initiators (CDs/SilMA) applied for DLP 3D bioprinting technology.

Tailoring the Coordination Microenvironment of Polymolybdate within a Metal-Organic Coordination System for Enhanced Capacitive Activity.

The design of a low-cost and efficient electrode material is crucial for electrochemical energy storage. Effectual utilization of polymolybdate as an electrode material for a supercapacitor is promising. Meanwhile, the coordination microenvironments of polymolybdate sho potential effects on its performance.

Superoxide is an Intrinsic Signaling Molecule Triggering Muscle Hypertrophy.

Redox signaling plays a key role in skeletal muscle remodeling induced by exercise and prolonged inactivity, but it is unclear which oxidant triggers myofiber hypertrophy due to the lack of strategies to precisely regulate individual oxidants . In this study, we used tetrathiomolybdate (TM) to dissociate the link between superoxide (O) and hydrogen peroxide and thereby to specifically explore the role of O in muscle hypertrophy in C2C12 cells and mice. TM can linearly regulate intracellular O levels by inhibition of superoxide dismutase 1 (SOD1).

Sn-based film electrodeposited on Ag foil for selective electrochemical CO reduction to CO.

Electrochemical CO reduction (ECR) to valuable chemicals and fuels using renewable energy is a promising way to reduce carbon emission. Herein, Sn-based films were electrodeposited on Ag foil surfaces (Sn/Ag-) for selective ECR to CO, where represented the concentration of SnCl in the electrodeposition bath. The Sn/Ag-20 electrode achieved a high CO faradaic efficiency of 96.

Correction for: Cornel iridoid glycoside exerts a neuroprotective effect on neuroinflammation in rats with brain injury by inhibiting NF-kB and STAT3.

[This corrects the article DOI: 10.1007/s13205-019-1697-5.].

Electron scattering beyond the independent atom model: Quantum fluctuation of the Coulomb potential.

In the past century, electron scattering has mostly served as a powerful tool to measure the microscopic structure of gases, liquids, and solids in either a static or time-resolved manner. One common basis for these works is the independent atom model, which directly relates electron scattering signals to the atomic structure of matter. In this perspective, we explore the information content of electron scattering that goes beyond the independent atom model.

Establishment of a hybrid model of atherosclerosis and acute colitis in ApoE-/- mice.

Inflammatory bowel disease (IBD) and atherosclerosis (AS) are both common chronic inflammatory diseases with similar pathophysiological mechanisms. Some studies have shown that IBD patients are at increased risk for early atherosclerosis, myocardial infarction and venous thrombosis. Here we set up a hybrid mouse model associated with atherosclerosis and acute colitis in order to investigate the interplay of the two diseases.

Excessive linoleic acid induces muscle oxidative stress through 5-lipoxygenase-dependent peroxidation.

Oxidative stress in muscles is closely related to the occurrence of insulin resistance, muscle weakness and atrophy, age-related sarcopenia, and cancer. Aldehydes, a primary oxidation intermediate of polyunsaturated fatty acids, have been proven to be an important trigger for oxidative stress. However, the potential role of linoleic acid (LA) as a donor for volatile aldehydes to trigger oxidative stress has not been reported.