TRIM3 modulates cisplmatin-resistant of cervical squamous cell carcinoma via endoplasmic reticulum stress signaling in vitro.

TRIM3 is widely recognized as a tumor suppressor gene. However, its precise role in cervical squamous cell carcinoma (CESC) remains elusive. Here, we observed a significant decrease in the expression of TRIM3 in CESC cells.

Anomalous normal-state gap in an electron-doped cuprate.

In the underdoped n-type cuprate NdCeCuO, long-range antiferromagnetic order reconstructs the Fermi surface, resulting in a putative antiferromagnetic metal with small Fermi pockets. Using angle-resolved photoemission spectroscopy, we observe an anomalous energy gap, an order of magnitude smaller than the antiferromagnetic gap, in a wide portion of the underdoped regime and smoothly connecting to the superconducting gap at optimal doping. After considering all the known ordering tendencies in tandem with the phase diagram, we hypothesize that the normal-state gap in the underdoped n-type cuprates originates from Cooper pairing.

The effect of TFAP2A/ANXA8 axis on ferroptosis of cervical squamous cell carcinoma (CESC) in vitro.

Potential role and associated mechanisms of Annexin A8 (ANXA8), a member of the Annexins family, in cervical squamous cell carcinoma (CESC) are still unclear, despite being upregulated in various malignant tumors. Here, we observed a notably elevated expression of ANXA8 in CESC cells. The inhibition of ANXA8 amplified the susceptibility of CESC cells to Erastin and sorafenib-induced ferroptosis, whereas it exerted minimal influence on DPI7 and DPI10-induced ferroptosis.

MAD2L2, a key regulator in ovarian cancer and promoting tumor progression.

Ovarian cancer (OVCA), a prevalent gynecological malignancy, ranks as the fourth most common cancer among women. Mitotic Arrest Deficient 2 Like 2 (MAD2L2), a chromatin-binding protein and a component of DNA polymerase ζ, has been previously identified as an inhibitor of tumor growth in colorectal cancer. However, the roles of MAD2L2 in OVCA, including its expression, impact, and prognostic significance, remain unclear.

Regulatory mechanism of GPER in the invasion and migration of ectopic endometrial stromal cells in endometriosis.

Endometriosis (EMS) is a chronic inflammatory disorder of high incidence that causes serious reproductive consequences. High estrogen production is a consistently observed endocrine feature of EMS. The present study aims to probe the molecular mechanism of G protein-coupled estrogen receptor 1 (GPER) in the invasion and migration of ectopic endometrial stromal cells (Ect-ESCs) and provides a new rationale for EMS treatment.

Fatigue Behavior of the FGH96 Superalloy under High-Temperature Cyclic Loading.

Strain-controlled low-cycle fatigue (LCF) tests and stress-controlled creep-fatigue interaction (CFI) tests on the FGH96 superalloy were carried out at 550 °C to obtain the cyclic softening/hardening characteristics at different strain amplitudes and ratcheting strain characteristics under different hold time. The failure mechanism of the FGH96 superalloy under different loading conditions was analyzed through fracture observations. The results show that the FGH96 superalloy exhibits different cyclic softening/hardening characteristics at different strain amplitudes, and the introduction of the hold time at peak stress exacerbates the ratcheting strain of the FGH96 superalloy under asymmetric stress cycles.

Lipidomics analysis facilitate insight into the molecular mechanisms of urate nephropathy in a gout model induced by combination of MSU crystals injection and high-fat diet feeding.

Renal injury is one of the most common clinical manifestations of patients with hyperuricaemia/gout. The precise pathophysiological mechanism(s) for the renal injury is still unknown. Furthermore, it is also unclear whether the clinical therapies (e.

Analysis of gene expression profile of peripheral blood in alveolar and cystic echinococcosis.

RNA-sequencing (RNA-seq) is a versatile, high-throughput technology that is being widely employed for screening differentially expressed genes (DEGs) in various diseases. Echinococcosis, a globally distributed zoonosis, has been reported to impose a heavy disease burden in pastoral areas of China. Herein we aimed to explore the molecular mechanisms underlying echinococcosis.

Differentiated roles of Lifshitz transition on thermodynamics and superconductivity in LaSrCuO.

The effect of Lifshitz transition on thermodynamics and superconductivity in hole-doped cuprates has been heavily debated but remains an open question. In particular, an observed peak of electronic specific heat is proposed to originate from fluctuations of a putative quantum critical point (e.g.

The Circadian Gene NPAS2 Act as a Putative Tumor Stimulative Factor for Uterine Corpus Endometrial Carcinoma.

Background: Mounting evidence indicates altered circadian rhythm represents a critical factor affecting carcinogenesis and tumor progression. The circadian gene neuronal PAS domain protein 2 (NPAS2) constitutes a newly discovered prognostic biomarker. NPAS2 dysregulation is found in multiple malignancies, although its functions in uterine corpus endometrial carcinoma (UCEC) remain largely unknown.

The Coronavirus Disease 2019 Pandemic Impacts Burnout Syndrome Differently Among Multiprofessional Critical Care Clinicians-A Longitudinal Survey Study.

Objectives: To determine the impact of coronavirus disease 2019 on burnout syndrome in the multiprofessional ICU team and to identify factors associated with burnout syndrome.

Design: Longitudinal, cross-sectional survey.

Setting: All adult ICUs within an academic health system.

Withaferin A inhibits proliferation of human endometrial cancer cells via transforming growth factor-β (TGF-β) signalling.

The present study was designed to evaluate the anticancer effects of withaferin A against the human endometrial cancer via modulation of transforming growth factor-β (TGF-β) signalling. The results of the present study revealed that withaferin A exerts a dose and time-dependent antiproliferative effects against the human KLE endometrial cancer cells with comparatively lower toxicity against the THESCs normal cells. The IC of withaferin A against the KLE endometrial cancer cells was found to 10 μM.

Multi-variable classification model for valve internal leakage based on acoustic emission time-frequency domain characteristics and random forest.

To use acoustic-emission technology to detect leaks inside valves, the necessary first step is to model the valve-internal-leakage acoustic-emission signal (VILAES) mathematically. A multi-variable classification model that relates the VILAES characteristics and the leakage rate under varying pressure is built by combining time-frequency domain characteristics and the random-forest method. A Butterworth bandpass filter is used to preprocess the VILAES from a liquid medium, and the best frequency band for filtering is determined as being 140 kHz-180 kHz.

Assessment of a 10-year dog deworming programme on the transmission of Echinococcus multilocularis in Tibetan communities in Sichuan Province, China.

Human alveolar echinococcosis (AE) is considered a neglected zoonotic disease by the World Health Organization (WHO). The causative pathogen, Echinococcus multilocularis, lives as an adult tapeworm in the intestinal tract of canines. AE was identified as an emerging public health issue in Tibetan communities of Shiqu County 20 years ago.

Metallic surface states in a correlated d-electron topological Kondo insulator candidate FeSb.

The resistance of a conventional insulator diverges as temperature approaches zero. The peculiar low-temperature resistivity saturation in the 4f Kondo insulator (KI) SmB has spurred proposals of a correlation-driven topological Kondo insulator (TKI) with exotic ground states. However, the scarcity of model TKI material families leaves difficulties in disentangling key ingredients from irrelevant details.

Electromagnetic and microwave absorption properties of iron pentacarbonyl pyrolysis-synthesized carbonyl iron fibers.

The present study executed iron pentacarbonyl pyrolysis to synthesize one-dimensional structured carbonyl iron fibers (CIFs) carrier gas induced flow. The obtained CIFs with a diameter of 100-300 nm and length-diameter ratio of more than 20, are actually composed of a large number of nanocrystalline aggregates. We investigated the dependence of the structure, morphology, and static magnetic and electromagnetic properties of the CIFs on the pyrolysis temperatures.

MiR-486-5p Act as a Biomarker in Endometrial Carcinoma: Promotes Cell Proliferation, Migration, Invasion by Targeting MARK1.

Background: miRNA expression acts as a potential biomarker in many diseases including endometrial carcinoma (EC). miR-486-5p dysregulation is observed in several tumor types, but the roles of miR-486-5p in EC are hardly ever studied.

Objective: This study aimed to analyze the expression profile of miR-486-5p in tumor tissues and serum samples of patients with EC and explore the target prediction, function analysis and validation in immortal cell lines.

Incoherent strange metal sharply bounded by a critical doping in Bi2212.

In normal metals, macroscopic properties are understood using the concept of quasiparticles. In the cuprate high-temperature superconductors, the metallic state above the highest transition temperature is anomalous and is known as the "strange metal." We studied this state using angle-resolved photoemission spectroscopy.

Peak-to-peak standard deviation based bubble detection method in sodium flow with electromagnetic vortex flowmeter.

The steam generator (SG) is a heat exchange device between a sodium coolant and water in sodium-cooled fast reactors. Its transfer tubes are prone to leakage to result in sodium-water reaction, which will affect the operational safety of the entire nuclear reactor. To this end, a signal processing method is studied to detect the SG leakage using an electromagnetic vortex flowmeter (EVFM).

Fermi surface reconstruction in electron-doped cuprates without antiferromagnetic long-range order.

Fermi surface (FS) topology is a fundamental property of metals and superconductors. In electron-doped cuprate Nd Ce CuO (NCCO), an unexpected FS reconstruction has been observed in optimal- and overdoped regime ( = 0.15-0.

Echo signal envelope fitting based signal processing methods for ultrasonic gas flow-meter.

The echo signal of the ultrasonic gas flow-meter is difficult to locate, and the computation of signal processing methods proposed by others is extensive which affects the meter's real-time performance. Aiming at solving these problems the echo signal envelopes under different flow rates are analyzed. And three kinds of signal processing methods based on echo signal envelope fitting are proposed.

Geographic distribution of echinococcosis in Tibetan region of Sichuan Province, China.

Background: Echinococcosis is a parasitic zoonosis caused by Echinococcus larvae parasitism causing high mortality. The Tibetan Region of Sichuan Province is a high prevalence area for echinococcosis in China. Understanding the geographic distribution pattern is necessary for precise control and prevention.

Transient process based electromagnetic flow measurement methods and implementation.

The ordinary electromagnetic flowmeter (EMF) utilizes the steady-state period of the excitation current for measuring the flow rate in order to ensure zero stability and measurement accuracy. In this paper, the transient process of EMF is studied to measure the flow rate so as to realize applications requiring ultra-low power consumption, for example, water meters. For this reason, the dynamic excitation current and signal voltage of the transient process are analyzed, and three kinds of transient measurement methods are proposed to determine the relationship between the processing results of the signal voltage and flow rates.