Design and synthesis of novel structures with anti-tumor effects: Targeting telomere G-quadruplex and hTERT.

The telomeric G-quadruplex (G4) along with the telomerase catalytic subunit hTERT are crucial in the extension of telomeres. Tumor cells can establish replicative immortality by activating the telomere-maintenance mechanism (TMM).Small molecule ligands can limit cancer telomere lengthening by by targeting at G4 and hTERT.

[Characterization and Source Apportionment of Polycyclic Aromatic Hydrocarbons in PM in Lanzhou].

To study the pollution characteristics and sources of 16 PAHs in PM in Lanzhou, PM samples were collected in four seasons. GC-MS was employed to analyze the concentration of PAHs. Positive matrix factorization(PMF), trajectory cluster, and potential source contribution function(PSCF) were used to identify the sources of PAHs.

A wave-confining metasphere beamforming acoustic sensor for superior human-machine voice interaction.

Highly sensitive, source-tracking acoustic sensing is essential for effective and natural human-machine interaction based on voice. It is a known challenge to omnidirectionally track sound sources under a hypersensitive rate with low noise interference using a compact sensor. Here, we present a unibody acoustic metamaterial spherical shell with equidistant defected piezoelectric cavities, referred to as the metasphere beamforming acoustic sensor (MBAS).

Platelet-Derived Growth Factor Predicts Vulnerable Plaque in Patients with Non-ST Elevation Acute Coronary Syndrome.

Background: Identifying a novel biomarker may contribute to detection of vulnerable plaque in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). The aim of this study was to investigate the relationship between serum platelet-derived growth factor (PDGF) and vulnerable plaque in patients with moderate and low risk of NSTE-ACS.

Methods: A total of 65 moderate- and low-risk NSTE-ACS patients with 50-90% coronary stenosis were divided into a vulnerable plaque group (n=46) and a stable plaque group (n=19) according to intravascular ultrasound (IVUS) examinations.