Ultrasensitive aflatoxin B1 detection based on vertical organic electrochemical transistor.

Herein, we presented an ultrasensitive Aflatoxin B1 (AFB1) detection platform based on vertical organic electrochemical transistor (vOECT) first time. Chitosan-graphene nanosheets nanocomposites and AFB1 antibodies were modified on commercial electrodes as immunosensors, in series with gate electrodes of vOECT, operated at enhancement mode with ultrahigh transconductance g 94 mS to amplify current signals. When AFB1 is added, the impedance of the immunosensors increased due to antigen-antibody immune binding, resulting in a potential decrease in reaction cell.

S-scheme MOF-on-MOF heterojunctions for enhanced photo-Fenton Cr(VI) reduction and antibacterial effects.

The photocatalytic efficiency is commonly restrained by inferior charge separation rate. Herein, the S-scheme MIL-100(Fe)/NH-MIL-125(Ti) (MN) photo-Fenton catalyst with the built-in electric field (BEF) was successfully constructed by a simple ball-milling technique. As a result, the MN-3 (the mass ratio of MIL-100(Fe) to NH-MIL-125(Ti) was 3) composite presented the best visible-light-induced photocatalytic ability, in contrast to pure MIL-100(Fe) and NH-MIL-125(Ti).

Solution-Processed Flexible Transparent Electrodes for Printable Electronics.

Flexible transparent electrodes (FTEs) have been widely witnessed in various printable electronic devices, especially those involving light. So far, solution processes have demonstrated increasing advantages in preparing FTEs not only in their mild operation conditions and high-throughput but also in the diversity in micropatterning conductive nanomaterials into networks. For the FTEs, both high transparency and high conductivity are desirable, which therefore create requirements for the conductive network by considering the trade-off relationship between the coverage and the micropatterns of the network.

Relapsed/refractory acute promyelocytic leukemia with RARA-LBD region mutation was salvaged by venetoclax: A case report.

Rationale: Acute promyelocytic leukemia (APL) is one of the most curable cancers. However, relapse of the disease is a difficult issue in clinical practice and it remains a great challenge that patients have a poor effect of conventional treatment in the clinic. Therefore, new and more effective therapeutic measures are urgently needed.

CB-LPD, MGUS, T-LGLL, and PRCA: A rare case report of 4 concomitant hematological disorders.

Rationale: Monoclonal gammopathy of undetermined significance (MGUS) is a clinically asymptomatic clonal plasma cell or lymphoplasmacytic proliferative disorder. Recently, some case reports have described the association of pure red cell aplasia (PRCA) with MGUS, even with a relatively low monoclonal immunoglobulin burden. T large granular lymphocyte leukemia (T-LGLL) is a chronic lymphoproliferative disorder characterized by clonal expansion of T large granular lymphocytes, which is rare in China.

Development and validation of a nomogram for steroid-resistance prediction in immune thrombocytopenia patients.

Objectives: Corticosteroid is first-line therapy in immune thrombocytopenia. However, nearly 30% of patients appear in steroid-resistance. Our research analyses the relevant indicators of patients and develops a risk prediction model to predict the poor response to steroid-therapy in ITP patients.

Single cell RNA-seq data and bulk gene profiles reveal a novel signature of disease progression in multiple myeloma.

Background: The development of multiple myeloma (MM) is considered to involve a multistep transformation process, but the role of cytogenetic abnormalities and molecular alterations in determining the cell fate of multiple myeloma (MM) remains unclear. Here, we have analyzed single cell RNA-seq data and bulk gene profiles to reveal a novel signature associated with MM development.

Methods: The scRNA-seq data from GSE118900 was used to profile the transcriptomes of cells from MM patients at different stages.

Upregulation of P53 promotes nucleus pulposus cell apoptosis in intervertebral disc degeneration through upregulating NDRG2.

P53 is an apoptosis marker which is involved in determining nucleus pulposus (NP) cell fate. Little is known about P53 interaction with N-Myc downstream-regulated gene 2 (NDRG2) in intervertebral disc degeneration (IVDD). Here, we studied the role of the P53-NDRG2 axis in IVDD.

Ultrafast Self-Propelled Directional Liquid Transport on the Pyramid-Structured Fibers with Concave Curved Surfaces.

Self-propelled directional liquid transport (SDLT) has been observed on many natural substrates, serving as an efficient strategy to utilize surrounding liquids for a better habitat to the local environment. Drawing inspiration, various artificial materials capable of SDLT have been developed. However, the liquid transport velocity is normally very low (ca.

Preparation of pyramidal SnO/CeO nano-heterojunctions with enhanced photocatalytic activity for degradation of tetracycline.

Pyramidal SnO/CeO nano-heterojunction photocatalysts were successfully synthesized via a facile hydrothermal method. The structural characterization was investigated by using common characterization tools. The content of SnO affected the morphology and photocatalytic performance of the SnO/CeO nano-heterojunctions.

Successful treatment of disseminated fusariosis in a patient with acute lymphoblastic leukemia: A case report and literature review.

Rationale: Fusarium is the second most common cause of fungi infections in the immunocompromised patients with the mortality rate over 80%. Early identification and appropriate selection of antifungal drugs is the key to successful treatment.

Patient Concerns: A 31-year-old female was diagnosed with acute lymphocytic leukemia (pro-B ALL).

Dasatinib and chemotherapy in a patient with early T-cell precursor acute lymphoblastic leukemia and fusion: A case report.

The present study aimed to evaluate the therapeutic efficacy of dasatinib in a patient with nucleoporin 214-tyrosine protein kinase ABL1 proto-oncogene 1 -positive early T-cell precursor-acute lymphoblastic leukemia (ETP-ALL), as well as that of selinexor and dasatinib for -positive ETP-ALL . ETP leukemia is a form of T-cell ALL (T-ALL) with poor prognosis. The gene is present in ~6% of T-ALL cases, however the prevalence of gene expression in ETP-ALL in particular has not yet been verified.

Small molecule-driven directional movement enabling pin-hole free perovskite film via fast solution engineering.

Organolead trihalide perovskite materials have been widely used as light absorbers in efficient photovoltaic cells. Solution engineering is a fast and effective method to fabricate perovskite films. Here, we report a fast precipitation of a pin-hole free perovskite film by small molecule-driven directed diffusion engineering.

Carfilzomib Inhibits Constitutive NF-κB Activation in Mantle Cell Lymphoma B Cells and Leads to the Induction of Apoptosis.

Mantle cell lymphoma (MCL) remains incurable and new treatments are needed, especially in the relapsed/refractory setting. We therefore investigated the effects of carfilzomib, a novel, long-acting, second-generation proteasome inhibitor, in MCL cells. Eight established MCL cell lines and freshly isolated primary MCL cells were treated with carfilzomib.

Magic year for multiple myeloma therapeutics: Key takeaways from the ASH 2015 annual meeting.

Despite the availability of various anticancer agents, Multiple Myeloma (MM) remains incurable in most cases, along with high relapse rate in the patients treated with these agents. The year 2015 saw major advancements in our battle against multiple myeloma. In 2015, the U.

[Expression of pituitary tumor transforming gene in patients with acute lymphoblastic leukemia].

The aim of this study was to explore the expression of pituitary tumor-transforming gene (PTTG) in acute lymphoblastic leukemia (ALL) and its relationship with the pathogenesis of ALL, as well as study the difference of the PTTG expression in ALL patients with Ph1 chromosome and without Ph1 chromosome. The mRNA expressions of PTTG in bone marrow from 28 patients with ALL and 28 normal controls were quantitatively detected by real-time quantitative polymerase chain reaction (real-time PCR). The results indicated that the expression of PTTG mRNA was significantly higher in ALL patients (1.

Potential effects of CRM1 inhibition in mantle cell lymphoma.

Mantle cell lymphoma (MCL) is an aggressive histotype of B-cell non-Hodgkin lymphoma. The disease has no known cure, which prompts the urgent need for novel therapeutic agents. Chromosomal region maintenance 1 (CRM1) may play a role in human neoplasia and serve as a novel target of cancer treatment.

Novel selective inhibitors of nuclear export CRM1 antagonists for therapy in mantle cell lymphoma.

Overexpression of the cellular nuclear exportin 1, more commonly called chromosomal region maintenance 1 (CRM1), has been associated with malignant progression and mortality. Therefore, activation of nuclear export can play a significant etiologic role in some forms of human neoplasia and serve as a novel target for the treatment of these cancers. Mantle cell lymphoma (MCL) is an aggressive histotype of B-cell non-Hodgkin lymphoma that remains incurable.

Parthenolide induces apoptosis and lytic cytotoxicity in Epstein-Barr virus-positive Burkitt lymphoma.

Burkitt lymphoma (BL) has been reported to be strongly associated with Epstein-Barr virus (EBV) infection. The fact that EBV is generally present in cancer cells but rarely found in healthy cells represents an opportunity for targeted cancer therapy. One approach is to activate the lytic replication cycle of the latent EBV.

3,4,7,8-Tetra-methyl-1,10-phenanthrolin-1-ium nitrate monohydrate.

In the crystal of the title compound, C(16)H(17)N(2) (+)·NO(3) (-)·H(2)O, the tetra-methyl-1,10-phenanthrolinium cations, nitrate anions and lattice water mol-ecules are all located on a mirror plane with the methyl H atoms of the cation equally disordered over two sites about the mirror plane. The cation, anion and water mol-ecule are linked by O-H⋯O and N-H⋯O hydrogen bonds into a sheet parallel to the bc plane. π-π stacking between phenanthroline ring systems is observed in the crystal structure, the centroid-centroid distance being 3.

Triazole-forming waterborne polyurethane composites fabricated with silane coupling agent functionalized nano-silica.

In the research work, "click" chemistry was used to modify waterborne polyurethane (WPU) with silane coupling agent (SiCA) functionalized nano-silica. The modified WPU (CWPU) was characterized by FTIR, scanning electron microscope (SEM), thermogravimetric analysis (TGA) and contact angle measurement. The experiment results show that the modification can improve the thermal stability, hardness, and water or weather resistance of CWPU.