Optic nerve sheath diameter/eyeball transverse diameter ratio by ultrasound in prediction of increased intracranial pressure in children with viral encephalitis.

Introduction: Increased intracranial pressure (ICP) is common with viral encephalitis in children which is associated with complications and prognosis. The optic nerve sheath diameter (ONSD) is a new indicator for the assessment of intracranial pressure using ultrasound, CT scan and MRI imaging. Given the influence of physical development on ONSD size in children, we expect more accurate assessment of intracranial pressure with ONSD/ETD (eyeball transverse diameter) ratio by ultrasound.

InGaP χ integrated photonics platform for broadband, ultra-efficient nonlinear conversion and entangled photon generation.

Nonlinear optics plays an important role in many areas of science and technology. The advance of nonlinear optics is empowered by the discovery and utilization of materials with growing optical nonlinearity. Here we demonstrate an indium gallium phosphide (InGaP) integrated photonics platform for broadband, ultra-efficient second-order nonlinear optics.

Low-loss adiabatic fiber-optic coupler for cryogenic photonics.

Recent developments in quantum light-matter coupled systems and quantum transducers have highlighted the need for cryogenic optical measurements. In this study, we present a packaged fiber-optic coupler with a coupling efficiency of over 50% for telecom wavelength light down to the mK temperature range. Besides the high coupling efficiency, our method enables sensitive photonic device measurements that are immune to mechanical vibrations present in cryogenic setups.

ColdDTA: Utilizing data augmentation and attention-based feature fusion for drug-target binding affinity prediction.

Accurate prediction of drug-target affinity (DTA) plays a crucial role in drug discovery and development. Recently, deep learning methods have shown excellent predictive performance on randomly split public datasets. However, verifications are still required on this splitting method to reflect real-world problems in practical applications.

Optomechanical crystal with bound states in the continuum.

Chipscale micro- and nano-optomechanical systems, hinging on the intangible radiation-pressure force, have shown their unique strength in sensing, signal transduction, and exploration of quantum physics with mechanical resonators. Optomechanical crystals, as one of the leading device platforms, enable simultaneous molding of the band structure of optical photons and microwave phonons with strong optomechanical coupling. Here, we demonstrate a new breed of optomechanical crystals in two-dimensional slab-on-substrate structures empowered by mechanical bound states in the continuum (BICs) at 8 GHz.

Observation of phonon trapping in the continuum with topological charges.

Phonon trapping has an immense impact in many areas of science and technology, from the antennas of interferometric gravitational wave detectors to chip-scale quantum micro- and nano-mechanical oscillators. It usually relies on the mechanical suspension-an approach, while isolating selected vibrational modes, leads to serious drawbacks for interrogation of the trapped phonons, including limited heat capacity and excess noises via measurements. To circumvent these constraints, we realize a paradigm of phonon trapping using mechanical bound states in the continuum (BICs) with topological features and conducted an in-depth characterization of the mechanical losses both at room and cryogenic temperatures.

Anomalous Quantum Hall Effect of Light in Bloch-Wave Modulated Photonic Crystals.

Effective magnetic fields have enabled unprecedented manipulation of neutral particles including photons. In most studied cases, the effective gauge fields are defined through the phase of mode coupling between spatially discrete elements, such as optical resonators and waveguides in the case for photons. Here, in the paradigm of Bloch-wave modulated photonic crystals, we show the creation of effective magnetic fields for photons in conventional dielectric continua for the first time, via Floquet band engineering.

Mechanical bound states in the continuum for macroscopic optomechanics.

Bound states in the continuum (BICs), an emerging type of long-lived resonances different from the cavity-based ones, have been explored in several classical systems, including photonic crystals and surface acoustic waves. Here, we reveal symmetry-protected mechanical BICs in the structure of slab-on-substrate optomechanical crystals. Using a group theory approach, we identified all the mechanical BICs at the Γ point in optomechanical crystals with C and C symmetries as examples, and analyzed their coupling with the co-localized optical BICs and guided resonances due to both moving boundary and photo-elastic effects.

Two-dimensional Green's tensor for gyrotropic clusters composed of circular cylinders.

The construction of Green's tensor for two-dimensional gyrotropic photonic clusters composed of cylinders with circular cross sections using the semi-analytic multipole method is presented. The high efficiency and accuracy of the method is demonstrated. The developed method is applied to gyrotropic clusters that support topological chiral Hall edge states.

Photonic Aharonov-Bohm effect in photon-phonon interactions.

The Aharonov-Bohm effect is one of the most intriguing phenomena in both classical and quantum physics, and associates with a number of important and fundamental issues in quantum mechanics. The Aharonov-Bohm effects of charged particles have been experimentally demonstrated and found applications in various fields. Recently, attention has also focused on the Aharonov-Bohm effect for neutral particles, such as photons.

Controlling the flow of light using the inhomogeneous effective gauge field that emerges from dynamic modulation.

We show that the effective gauge field for photons provides a versatile platform for controlling the flow of light. As an example we consider a photonic resonator lattice where the coupling strength between nearest neighbor resonators are harmonically modulated. By choosing different spatial distributions of the modulation phases, and hence imposing different inhomogeneous effective magnetic field configurations, we numerically demonstrate a wide variety of propagation effects including negative refraction, one-way mirror, and on- and off-axis focusing.

Photonic de Haas-van Alphen effect.

Based on the recently proposed concept of effective gauge potential and magnetic field for photons, we numerically demonstrate a photonic de Haas-van Alphen effect. We show that in a dynamically modulated photonic resonator lattice exhibiting an effect magnetic field, the trajectories of the light beam at a given frequency have the same shape as the constant energy contour for the photonic band structure of the lattice in the absence of the effective magnetic field.

High-sensitivity magnetometry based on quantum beats in diamond nitrogen-vacancy centers.

We demonstrate an absolute magnetometer based on quantum beats in the ground state of nitrogen-vacancy centers in diamond. We show that, by eliminating the dependence of spin evolution on the zero-field splitting D, the magnetometer is immune to temperature fluctuation and strain inhomogeneity. We apply this technique to measure low-frequency magnetic field noise by using a single nitrogen-vacancy center located within 500 nm of the surface of an isotopically pure (99.

Photonic Aharonov-Bohm effect based on dynamic modulation.

We show that when the refractive index of a photonic system is harmonically modulated, the phase of the modulation introduces an effective gauge potential for photons. This effective gauge potential can be used to create a photonic Aharonov-Bohm effect. We show that the photonic Aharonov-Bohm effect provides the optimal mechanism for achieving complete on-chip nonmagnetic optical isolation.

Ultracompact nonreciprocal optical isolator based on guided resonance in a magneto-optical photonic crystal slab.

We design an ultracompact optical isolator with normal incident geometry that operates with a bandwidth that is substantial for a device of this size. For operation in a telecommunication wavelength of 1.55 μm, the thickness of the device is less than 1 μm and the device supports an operating bandwidth of 400 GHz over which the minimum contrast ratio exceeds 25 dB.