Publications by authors named "Kejian Wen"
Chronic kidney diseases (CKD) is a serious threat to people's health with renal fibrosis as the major pathological feature. The absent in melanoma 2 (AIM2) has recently been proposed to play a critical role in CKD. Emodin is a major bioactive compound from rhubarb, which is widely used for clinical treatment of renal disease.
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- Study Aim
- : The research focused on exploring how chrysophanol affects kidney fibrosis and the underlying molecular mechanisms involved.
- Methods Used
- : Researchers utilized pharmacological analysis and both animal and cell models after inducing chronic kidney disease to investigate chrysophanol’s effects, measuring renal function and identifying key biochemical pathways involved.
- Key Findings
- : Chrysophanol significantly improved kidney function in mice and reduced oxidative stress while enhancing the protective Trx-1 pathway, suggesting its potential as a treatment for renal fibrosis.