Publications by authors named "Keizo Hiramatsu"

Purpose: Premenstrual symptoms can negatively impact the quality of life of women through a range of mood, behavioral, and physical symptoms. The association between the microbiota and brain function has been extensively studied. Here, we examined the characteristics of the microbiota in women with premenstrual disorders (PMDs) and the association between premenstrual symptoms and the microbiota.

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Article Synopsis
  • - The study developed an AI system for diagnosing uterine cervical lesions using 463 colposcopic images and compared its accuracy with traditional diagnoses from gynecologists.
  • - AI showed varying accuracy rates: 57.8% for normal lesions, and lower rates for cervical intraepithelial neoplasia (CIN) and invasive cancer, while gynecologists had initial accuracy rates of around 54% for CIN2-3 and 39% for invasive cancer.
  • - After being informed of the AI diagnoses, gynecologists improved their accuracy, indicating that AI-assisted image diagnosis (AISD) significantly enhances the diagnostic capability for invasive cancer and shows potential benefits for CIN2-3.
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Aim: Consumption of isoflavones, which are predominantly derived from soybeans, reduces the risk of estrogen-related diseases, such as menopausal symptoms, breast cancer, osteoporosis, and cardiovascular disease. Equol is more bioavailable than other soy isoflavones, and equol producers are believed to benefit to a greater extent. This study was conducted to evaluate the relation between premenstrual syndrome (PMS) and equol-production status in Japanese reproductive-age women.

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Aim: A combined oral contraceptive containing ethinylestradiol 20 µg plus drospirenone 3 mg (EE20 + DRSP) in a 24/4 regimen has been shown to alleviate the symptoms of premenstrual syndrome and premenstrual dysphoric disorder. This study was conducted to evaluate the efficacy of EE20 + DRSP in Japanese patients with premenstrual symptoms.

Material And Methods: A multicenter, prospective, open-label, single-arm, phase IV study was performed in Japanese women with dysmenorrhea and premenstrual symptoms.

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Morphology and function (secretion of thyroid hormone) of human thyroid tissues from Graves' disease patients are well maintained in C57BL/6J-scid mice. Serum level of thyroid hormone was reduced by fission neutrons from the nuclear reactor UTR-KINKI, and changes in thyroid hormone by fission neutrons were bigger than those by low LET radiations, X-rays and (137)Cs gamma-rays, suggesting high relative biological effectiveness (RBE; 6.5) of fission neutrons.

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