Publications by authors named "Keith Wong"

Triplet-state dissolved organic matter (DOM*) plays a crucial role in environmental aquatic photochemistry, with 2,4,6-trimethylphenol (TMP) frequently used as a chemical probe or quencher due to its high reactivity with DOM*. However, the influence of TMP-derived oxidation intermediates on the target photochemical reactions has not been comprehensively examined. This study investigated TMP's effect on the photolysis of sulfamethoxazole (SMX), a common antibiotic found in natural waters, in the presence of different DOM sources or model photosensitizer.

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The role of non-invasive ventilation (NIV) in patients with cystic fibrosis (pwCF) includes use in both the management of hypercapnic respiratory failure and as an adjunct to airway clearance techniques. We performed a retrospective review of the Australian Cystic Fibrosis Data Registry to analyse the characteristics of pwCF requiring NIV. We demonstrated that despite improvements in overall health in pwCF there is still a significant role of NIV in this population.

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Naturopathic practitioners consult an estimated 6.2% of Australian adults, equating to 1,550,000 people receiving their care each year. Sleep is now recognized as a key pillar of health; however, nearly half of all Australian adults report inadequate sleep.

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Digital cognitive behavioural therapy for insomnia has been developed to increase capacity and scalability for patients with insomnia, but implementation in primary care remains limited. The aim of the trial was to evaluate the implementation of digital insomnia therapy into primary care practice for patients with insomnia. We conducted a single-arm feasibility trial of digital behavioural therapy for insomnia (SleepFix) providing sleep restriction therapy with insomnia patients in primary care.

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Article Synopsis
  • Patients with COPD/OSA overlap syndrome (OVS) have a better prognosis than those with COPD alone, especially in stable outpatients.
  • In a study of 168 patients, those with OVS showed improved median survival rates and lower mortality, particularly when discharged with home positive airway pressure (PAP) therapy.
  • Although the initial analysis indicated significant differences in mortality rates favoring OVS, further adjustments suggest that the difference may not be statistically conclusive after accounting for confounders.
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Article Synopsis
  • Most research on precision medicine for obstructive sleep apnea (OSA) focuses on sleep parameters, but this study highlights the importance of wakefulness physiology measures for predicting OSA therapies.
  • The study investigated the relationship between awake ventilatory control and OSA endotypes, analyzing data from a trial comparing morphine and placebo effects on OSA severity.
  • Findings showed that awake chemosensitivity correlates with critical airway pressures and can predict changes in OSA severity when administered morphine, suggesting awake measures could enhance understanding of OSA physiology.
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A series of arylsulfones and heteroarylsulfones have previously been demonstrated to dysregulate the conserved bacterial ClpP protease, causing the unspecific degradation of essential cellular housekeeping proteins and ultimately resulting in cell death. A cocrystal structure of a 2-β-sulfonylamide analog, ACP1-06, with ClpP showed that its 2-pyridyl sulfonyl substituent adopts two orientations in the binding site related through a sulfone bond rotation. From this, a new -aryl phosphine oxide scaffold, designated as ACP6, was designed based on a "conformation merging" approach of the dual orientation of the ACP1-06 sulfone.

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Despite a high detection rate of Ga-prostate-specific membrane antigen (PSMA) PET/CT in biochemical recurrence (BCR) of prostate cancer, a significant proportion of men have negative Ga-PSMA-11 PET/CT results. Gastrin-releasing peptide receptor, targeted by the copper-chelated bombesin analog Cu-sarcophagine-bombesin (SAR-BBN) PET/CT, is also overexpressed in prostate cancer. In this prospective imaging study, we investigate the detection rate of Cu-SAR-BBN PET/CT in patients with BCR and negative or equivocal Ga-PSMA-11 PET/CT results.

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Background: Pulse oximetry is widely used in the assessment of chronic respiratory failure in neuromuscular disease (NMD) patients. Chronic respiratory failure is the major cause of morbidity and mortality, necessitating early diagnosis and intervention. Guidelines suggest that an arterial blood gas (ABG) measurement is indicated if oxygen saturation ( ) is ≤94% in the absence of lung disease.

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Study Objectives: Symptom impact and neurocognitive function have not been previously compared between patients with obesity-associated hypoventilation disorders (obesity hypoventilation syndrome [OHS]) and hypoventilation in the setting of obesity and obstructive airways disease (OHAD). The aim of this study is to compare baseline sleep-related symptoms, health-related quality of life, and neurocognitive function between OHS and OHAD and the impact of PAP therapy on these outcomes.

Methods: Epworth Sleepiness Scale (ESS), Pittsburgh Sleepiness Quality Index (PSQI), SF36, and various neurocognitive tests, in addition to anthropometric, polysomnography, lung function, and blood gas data from participants with OHS and participants with OHAD, were included in the analysis.

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Meeting the demand for efficient photosensitizers in photodynamic therapy (PDT), a series of iridium(III) complexes decorated with silicane-modified rhodamine (Si-rhodamine) was meticulously designed and synthesized. These complexes demonstrate exceptional PDT potential owing to their strong absorption in the near-infrared (NIR) spectrum, particularly responsive to 808 nm laser stimulation. This feature is pivotal, enabling deep-penetration laser excitation and overcoming depth-related challenges in clinical PDT applications.

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The efficacy of photodynamic therapy (PDT) is highly dependent on the photosensitizer features. The reactive oxygen species (ROS) generated by photosensitizers is proven to be associated with immunotherapy by triggering immunogenic cell death (ICD) as well. In this work, we establish a rhodamine-iridium(III) hybrid model functioning as a photosensitizer to comprehensively understand its performance and potential applications in photodynamic immunotherapy.

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The PRIMARY score is a 5-category scale developed to identify clinically significant intraprostate malignancy (csPCa) on Ga-prostate-specific membrane antigen (PSMA)-11 PET/CT (Ga-PSMA PET) using a combination of anatomic site, pattern, and intensity. Developed within the PRIMARY trial, the score requires evaluation in external datasets. This study aimed to assess the reproducibility and diagnostic accuracy of the PRIMARY score in a cohort of patients who underwent multiparametric MRI (mpMRI) and Ga-PSMA PET before prostate biopsy for the diagnosis of prostate cancer.

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Selective and smooth low- SiO/AlO nanolaminate dielectric on dielectric (DOD) was achieved by a hybrid water-free pulsed CVD process consisting of 50 pulses of ATSB (tris(2-butoxy)aluminum) at 330 °C and a 60 s TBS (tris(-butoxy)silanol) exposure at 200 °C. Aniline selective passivation was demonstrated on W surfaces in preference to SiN and SiO at 300 °C. At 200 °C, TBS pulsed CVD exhibited no growth on W or SiO, but its growth was catalyzed by AlO.

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Background And Aims: The experience of outpatient care may differ for select patient groups. This prospective study evaluates the adult patient experience of multidisciplinary outpatient cystic fibrosis (CF) care with videoconferencing through telehealth compared with face-to-face care the year prior.

Methods: People with CF without a lung transplant were recruited.

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Study Objectives: Limited channel electroencephalography (EEG) investigations in obstructive sleep apnea (OSA) have revealed deficits in slow wave activity (SWA) and spindles during sleep and increased EEG slowing during resting wakefulness. High-density EEG (Hd-EEG) has also detected local parietal deficits in SWA (delta power) during NREM. It is unclear whether effective continuous positive airway pressure (CPAP) treatment reverses regional SWA deficits, and other regional sleep and wake EEG abnormalities, and whether any recovery relates to improved overnight memory consolidation.

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A series of platinum(II) bipyridine complexes with two rhodamine-like alkynyl (Rhodyne) ligands were developed to show chemo-induced "ON-OFF" switching capabilities with exceptional near-infrared phosphorescence and delayed fluorescence. This study contributes to the design of versatile photosensitizers with multiple functionalities, including metal ion and biomolecule sensing, photodynamic therapy, and optoelectronics.

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Introduction: While digital health interventions (DHIs) can potentially address the unmet needs for sleep health services, little is known about their implementation in practice. The current study aimed to explore primary care health providers' attitudes and beliefs towards DHIs for sleep and implementation into practice.

Methods: A cross-sectional online survey was administered to Australian primary care health professionals: general practitioners (GPs), community nurses, and community pharmacists.

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Selective and smooth dielectric-on-dielectric was achieved by water-free single-precursor chemical vapor deposition (CVD) processes with the help of aniline passivation. Aniline selective passivation was demonstrated on W surfaces in preference to SiO at 250, 300, and 330 °C. After aniline passivation, selective HfO, AlO, and TiO were deposited only on the HF-cleaned SiO surface by water-free single-precursor CVD using hafnium -butoxide Hf(OBu), aluminum-tri--butoxide (ATSB), and titanium isopropoxide Ti(OPr) as the precursor reactants, respectively.

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Megakaryocytes (MKs) are precursors to platelets, the second most abundant cells in the peripheral circulation. However, while platelets are known to participate in immune responses and play significant functions during infections, the role of MKs within the immune system remains largely unexplored. Histological studies of sepsis patients identified increased nucleated CD61 cells (MKs) in the lungs, and CD61 staining (likely platelets within microthrombi) in the kidneys, which correlated with the development of organ dysfunction.

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In contrast to the extensively studied dirhodium(II) complexes and iridium(III) complexes, neutral or dicationic dinuclear iridium(II) complexes with an unsupported ligand are underdeveloped. Here, a series of tetracationic dinuclear iridium(II) complexes, featuring the unsupported Ir(II)-Ir(II) single bond with long bond distances (2.8942(4)-2.

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The mitochondrial ClpP protease is responsible for mitochondrial protein quality control through specific degradation of proteins involved in several metabolic processes. ClpP overexpression is also required in many cancer cells to eliminate reactive oxygen species (ROS)-damaged proteins and to sustain oncogenesis. Targeting ClpP to dysregulate its function using small-molecule agonists is a recent strategy in cancer therapy.

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Background: Hypersomnias of central origin (HOCO) are diverse in origin and symptomatology and remain poorly described in an Australian population. We hypothesised that the rate of human leukocyte antigen (HLA) DQB1*0602 positivity in the Australian cohort would be comparable to international registries.

Aims: The current study aims to evaluate epidemiological and clinical characteristics of Australian patients with HOCO, including prevalence of HLA DQB1*0602 positivity, the most specific HLA marker associated with narcolepsy.

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Sleep restriction therapy (SRT) is an effective stand-alone behavioural intervention for insomnia disorder. However, its daytime side effects, particularly sleepiness, may be troubling for patients and/or may be a necessary part of the patient's treatment journey. This pilot trial aims to explore the potential benefit of armodafinil, a wakefulness promoter.

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