Publications by authors named "Keith McConn"
Article Synopsis
- AEC2 cells play a crucial role in lipid metabolism for surfactant production, which is vital for lung function.
- Chronic exposure to cigarette smoke disrupts lipid synthesis in these cells and is connected to the development of COPD.
- Mice lacking the FASN enzyme in AEC2 cells showed increased lung inflammation and altered surfactant composition, highlighting the enzyme's importance in how the lung responds to smoke exposure.
A 57-year-old man with high-grade synovial sarcoma was found to have cardiac involvement of his malignancy. Intracardiac tumor resulted in dynamic left ventricular outflow tract obstruction and severe mitral regurgitation. He underwent mitral valve replacement and had no cardiovascular symptoms at 1-year follow-up.
View Article and Find Full Text PDFChronic obstructive pulmonary disease (COPD) is marked by airway inflammation and airspace enlargement (emphysema) leading to airflow obstruction and eventual respiratory failure. Microvasculature dysfunction is associated with COPD/emphysema. However, it is not known if abnormal endothelium drives COPD/emphysema pathology and/or if correcting endothelial dysfunction has therapeutic potential.
View Article and Find Full Text PDF