Results of a 5-Year N-of-1 Growth Hormone Releasing Hormone Gene Therapy Experiment.

Here presented for the first time are results showing persistence over a 5+ year period in a human who had a hormone gene therapy administered to muscle. This growth hormone releasing hormone (GHRH) therapy was administered in two doses, a year apart, with a mean after the second dose of 195 ng/mL (13 × normal, σ = 143, σ = 34, max = 495, min = 53). This level of GHRH therapy appears to be safe for the subject, although there were some adverse events.