Use of an artificial lymphatic system during carboplatin infusion to improve canine osteosarcoma blood flow and clinical response.

Background: The artificial lymphatic system (ALS), a mechanical system designed to reduce increased interstitial fluid pressure in solid tumors and enhance the delivery of chemotherapy, was evaluated within a randomized clinical trial treating spontaneously occurring canine appendicular osteosarcoma (OS), a tumor similar to its human OS counterpart.

Methods: An ALS was investigated for its ability to increase OS blood flow and increase uptake of intravenously administered carboplatin.

Results: Blood flow increased by 314% in tumors with active ALS drains versus 126% in control tumors (P < .

Comparison of endoscopic and full-thickness biopsy specimens for diagnosis of inflammatory bowel disease and alimentary tract lymphoma in cats.

Objective: To evaluate the accuracy of endoscopic biopsy (EB) specimens for diagnosis of alimentary tract lymphosarcoma in cats.

Design: Prospective study.

Animals: 22 cats with inflammatory bowel disease (IBD) or alimentary tract lymphosarcoma.

Outcome following surgical removal of nonvisceral soft tissue sarcomas in cats: 42 cases (1992-2000).

Objective: To identify factors associated with outcome of cats with nonvisceral soft tissue sarcomas treated with surgery alone.

Design: Retrospective study.

Animals: 42 cats.

Use of a 13C-aminopyrine blood test: first clinical impressions.

The purpose of this study was to collect initial data to determine the potential clinical usefulness of a 13C-aminopyrine demethylation blood test, and whether additional clinical investigation is warranted. Six dogs, initially suspected of having hepatic disease based on their history, physical examination, imaging studies, general laboratory parameters, or any combination of the above, were enrolled in the study. A baseline blood sample was collected, 2 mg/kg 13C-aminopyrine was administered intravenously, and another blood sample was collected 45 min afterwards.

Feline esophagitis secondary to gastroesophageal reflux disease: clinical signs and radiographic, endoscopic, and histopathological findings.

Chronic esophagitis due to gastroesophageal reflux (GER) is rarely reported in the cat. This paper describes the clinical signs and diagnostic findings, including radiographic, endoscopic, and histopathological abnormalities, in three young, purebred, male cats with esophagitis presumed to be secondary to GER. Clinical signs included regurgitation, dysphagia, and weight loss.

Use of thoracoscopy to determine the etiology of pleural effusion in dogs and cats: 18 cases (1998-2001).

Objective: To assess use of thoracoscopy to determine causes of pleural effusion in dogs and cats.

Design: Retrospective study.

Animals: 15 dogs and 3 cats with pleural effusion.