Publications by authors named "Keita Kodera"
Article Synopsis
- Histone lactylation is a new epigenetic modification driven by lactate from glycolysis, which is often heightened in cancer, notably gastric cancer (GC), and is linked to poorer patient outcomes.
- In GC, increased levels of histone H3K18 lactylation correlate with worse prognosis, while SIRT1 plays a key role in regulating these levels by either promoting or diminishing H3K18la depending on its expression.
- Targeting the interplay between SIRT1, the lncRNA H19, and glycolysis presents a promising therapeutic approach for GC, showing significant anti-cancer effects while minimizing harm to normal cells.
Background: The aim of this study was to investigate the prognostic value of systematic inflammatory response in patients with lymph node-negative colorectal cancer.
Methods: We retrospectively investigated 245 patients with lymph node-negative colorectal cancer who underwent curative resection and evaluated the prognostic impact of systematic inflammatory response, which was represented by neutrophil-to-lymphocyte ratio (NLR), prognostic nutritional index (PNI), and C-reactive protein-to-albumin ratio (CAR). Then, the prognostic significance of the systematic inflammatory response on survival was analyzed using the Kaplan-Meier method in patients selected by propensity score matching (PSM) analysis.
Aim: Osteopenia and sarcopenia, features of the aging process, are recognized as major health problems in an aging society. This study investigated the prognostic impact of osteosarcopenia, the coexistence of osteopenia and sarcopenia, in older adults undergoing curative resection for colorectal cancer.
Methods: We retrospectively reviewed data of older adults aged 65-98 y who had undergone curative resection for colorectal cancer.
Article Synopsis
- Incisional hernia is a frequent issue after abdominal surgeries, particularly in obese patients; this study aimed to explore the link between sarcobesity and hernia development following laparoscopic colorectal cancer surgery.
- A total of 262 patients were analyzed, revealing that 16.8% developed incisional hernias, with significant risk factors identified, including female sex, various types of obesity, sarcobesity, and wound infections.
- The findings suggest that sarcobesity is a strong independent predictor of incisional hernia, highlighting the role of body composition in post-surgery complications.
Purpose: Cancer cachexia, a complex multifactorial syndrome associated with sarcopenia, negatively affects the quality of life and survival in patients with several cancers. We aimed to develop a new score for cachexia assessment and evaluate its effectiveness in the classification of patients undergoing radical resection for colorectal cancer.
Methods: This study included 396 patients who underwent radical resection for Stage I-III colorectal cancer.
Traumatic intrathoracic foreign bodies are said to occur in many cases when the patient himself/herself is aware of the trauma. However, at the time of injury, the patient may sometimes be accompanied by loss of consciousness. We report a case of traumatic intrathoracic foreign body that was difficult to diagnose due to loss of consciousness at the time of injury.
View Article and Find Full Text PDFBackground: Undifferentiated pleomorphic sarcoma (UPS) is a malignant soft tissue tumor that has been reclassified from malignant fibrous histiocytoma with the development of the pathological diagnosis. It principally occurs in the extremities but rarely occurs in the rectum. We herein report a rare case of UPS arising in the rectum.
View Article and Find Full Text PDFLymphangiomas are classified as lymphatic malformations, which are more common in children and rare in adults. It frequently occurs in the cervical and axillary regions and uncommonly in the retroperitoneum. A 39-year-old woman presented to our department for the investigation for a 55 mm asymptomatic mass in the right anterior adrenal cavity.
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- Extended excision of the area around invasive colon cancer may improve survival, but there are limited reports of metachronous lymph node metastases after colorectal cancer resection.
- A 67-year-old man was diagnosed with sigmoid colon cancer that led to intestinal blockage and underwent surgical resection, with no recurrence noted for the first year post-surgery.
- However, 1.5 years later, metastasis was discovered in the para-aortic lymph nodes, prompting a laparoscopic procedure to remove the affected lymph nodes.
Background: Neuroendocrine tumors (NETs) originate from neuroendocrine cells, which are found throughout the body. NETs occur principally in the gastrointestinal tract (approximately 65%) and bronchopulmonary tract (approximately 25%) but rarely occur in the presacral space. Aside from primary and metastatic lesions, there have been reports of NETs occurring in the presacral space arising from tailgut cysts, teratomas, and imperforate anus.
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