Publications by authors named "Keisuke Shinno"
Article Synopsis
- - The study aimed to compare how well brimonidine (BMD) and brinzolamide (BZM) are absorbed in the body when given together as a fixed-combination drug versus when they are administered separately to rabbits.
- - Researchers measured the concentration of both drugs in different parts of the eye and in the blood using advanced testing methods after administering the drugs in various formulations.
- - Results indicated that the fixed combination (FCBB) produced similar drug levels in the eye and bloodstream as the individual drugs, suggesting that the combined formulation may improve drug distribution, particularly in certain eye tissues, and that the timing of administration can affect absorption.
Introduction: This study was aimed to compare ocular tissue distribution and systemic exposure of brimonidine and timolol after single topical administration to rabbits of fixed-combination ophthalmic solution of 0.1% brimonidine tartrate and 0.5% timolol and single drugs (0.
View Article and Find Full Text PDFIntroduction: Azithromycin demonstrates high tissue distribution and prolonged elimination half-life. In this study, we monitored the pharmacokinetics of a single ophthalmic administration of 1% azithromycin ophthalmic solution containing polycarbophil in the extraocular tissues, including the eyelid, and compared it with that of two commercial ophthalmic products, 1.5% levofloxacin ophthalmic solution and 0.
View Article and Find Full Text PDFArticle Synopsis
- This study investigates how the pH of brimonidine ophthalmic solutions affects its distribution in the posterior ocular tissues of pigmented rabbits after topical administration.
- The research involved analyzing tissue samples at various time points post-administration of two different pH solutions (6.4 and 7.3) to compare brimonidine concentrations.
- Results show that while both pH levels lead to significant drug bioavailability, the increase from pH 6.4 to 7.3 boosts brimonidine levels in posterior ocular tissues, suggesting similar absorption in the aqueous humor.
Article Synopsis
- The study investigates how the concentration of brimonidine, an eye drop medication, in the vitreous (the gel-like substance in the eye) relates to its free concentration in the retina/choroid (the target area for the drug).
- Researchers conducted experiments on pigmented rabbits to measure brimonidine levels after administering the drops and studied its binding to melanin in the eye tissues.
- Results showed that the concentration of brimonidine in the vitreous is closely linked to the free concentration in the retina/choroid, suggesting that vitreous concentration can serve as an indicator of drug levels in this target area.