A role of nitrite reductase (NirBD) for NO homeostatic regulation in Streptomyces coelicolor A3(2).

Although nitric oxide (NO) is an important signaling molecule in bacteria and higher organisms, excessive intracellular NO is highly reactive and dangerous. Therefore, living cells need strict regulation systems for cellular NO homeostasis. Recently, we discovered that Streptomyces coelicolor A3(2) retains the nitrogen oxide cycle (NO→NO→NO→NO) and nitrite removal system.