Fumagillin inhibits growth of the enteric protozoan parasite by covalently binding to and selectively inhibiting methionine aminopeptidase 2.

Amebiasis is an important cause of morbidity and mortality worldwide, and caused by infection with the protozoan parasite . Metronidazole is currently the first-line drug despite adverse effects and concerns on the emergence of drug resistance. Fumagillin, a fungal metabolite from and its structurally related natural and synthetic compounds have been previously explored as potential anti-angiogenesis inhibitors for cancers, anti-microbial, and anti-obese compounds.

Isolation and Total Synthesis of Kinenzoline, an Antitrypanosomal Linear Depsipeptide Isolated from a Marine sp. Cyanobacterium.

Kinenzoline (), a new linear depsipeptide, was isolated from a marine sp. cyanobacterium. Its structure was elucidated by spectroscopic analyses and degradation reactions.