Publications by authors named "Keisuke Akita"
Article Synopsis
- The study aims to compare the effectiveness of controlled-release dinoprostone (PGE) vaginal inserts against mechanical dilation methods for inducing labor before the due date, as research shows PGE may reduce cesarean sections without increasing risks to newborns.
- The retrospective analysis involved 206 mothers at 37 to 39 weeks of gestation, evaluating perinatal outcomes and the success rates of vaginal deliveries within 48 hours of starting oxytocin augmentation.
- Results showed a higher success rate of vaginal delivery in the PGE group (80.4%) compared to the non-PGE group (66.2%), with no emergency cesarean sections in the PGE group, suggesting that PGE may be a beneficial option for elective labor
Origins of obesity in the womb: Fetal adiposity and its determinants.
J Obstet Gynaecol Res
December 2024
Article Synopsis
- Birth weight is a key factor in assessing risks for perinatal complications and future health issues in children, signaling the importance of fetal development.
- Maternal factors like obesity, overnutrition, and blood sugar levels (hyperglycemia) significantly influence fetal growth and body composition, which can lead to higher neonatal fat levels.
- Understanding how fetal fat mass is determined could guide clinical approaches to improve fetal health and help prevent childhood obesity and metabolic disorders later in life.
Article Synopsis
- - This study focused on identifying risk factors that lead to early insulin therapy (before 24 weeks) in pregnant women diagnosed with gestational diabetes early in their pregnancies (E-GDM).
- - The research analyzed 530 mothers and found that those requiring early insulin therapy had higher maternal age, pre-pregnancy BMI, and glucose levels compared to those managed with diet alone, while also noting lower Apgar scores in the early insulin group.
- - Findings suggest that diagnosing E-GDM using multiple abnormal oral glucose tolerance test values, particularly high 1-hour plasma glucose levels, could highlight the need for early insulin therapy; further investigation is encouraged.
To evaluate perinatal outcomes and risk factors for large for gestational age (LGA; birth weight over 90 percentile) in gestational diabetes diagnosed before 24 gestational weeks and treated with diet therapy alone until delivery (Diet Early gestational diabetes mellitus (Diet Early GDM)), we assessed the maternal characteristics and perinatal outcomes of patients with early GDM ( = 309) and normal glucose tolerance (NGT; = 309) at Keio University Hospital. The gestational weight gain (GWG) expected at 40 weeks was significantly lower in the Diet Early GDM group than in the NGT group. The Diet Early GDM group exhibited a significantly lower incidence of low birth weight (<2500 g) and higher Apgar score at 5 min than the NGT group.
View Article and Find Full Text PDFLate preterm (LP, born between 34 0/7 and 36 6/7 weeks of gestation) infants may experience several adverse outcomes, similar to those experienced by low birthweight (LBW, birthweight <2500 g) infants. However, while LP infants are often born with LBW, the association between LP and LBW remains unknown. This study aimed to investigate LBW rate and independent risk factors for LBW in LP singleton neonates.
View Article and Find Full Text PDFItching is the most important symptom in atopic dermatitis because the persistent scratching in response to itching aggravates the disease. However, the etiologic mechanisms of itching in atopic dermatitis remain uncertain. HR-1 hairless mice fed a special diet, HR-AD, develop atopic dermatitis-like symptoms with prolonged scratching episodes.
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