Publications by authors named "Keishi Tsuduki"
Background: Chronic obstructive pulmonary disease (COPD) is characterized by airway inflammation with endothelial dysfunction. Cadherins are adhesion molecules on epithelial (E-) and vascular endothelial (VE-) cells. Soluble (s) cadherin is released from the cell surface by the effects of proteases including matrix metalloproteinases (MMPs).
View Article and Find Full Text PDF. This study aimed to examine whether plasma levels of cathepsin S or its inhibitor, cystatin C, may serve as biomarkers for COPD. .
View Article and Find Full Text PDFChronic obstructive pulmonary disease (COPD) develops only in smoking-sensitive smokers and manifests heterogeneous phenotypes, including emphysema and non-emphysema types. We aimed to identify biomarkers related to the smoking-sensitivity and phenotypes of COPD. Among 240 smokers suggestive of COPD, we studied on four groups defined by % forced expiratory volume in one second (FEV1) and computed tomography-based pulmonary emphysema.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the relationship between comorbidities and health status in COPD patients using the COPD Assessment Test (CAT) to measure their quality of life.
- It enrolled 336 COPD patients and identified significant correlations between higher CAT scores and conditions like GERD, depression, arrhythmia, and anxiety.
- The findings suggest that clinicians should pay close attention to high CAT scores as they may indicate the presence of these comorbidities, which can sometimes go unnoticed.