Publications by authors named "Keishi Ouchi"
Hepatitis B virus (HBV) can be transmitted within a family, but an interspousal transmission in elderly cases is rare and the change of viral quasispecies during the event is unclear. We experienced two acute hepatitis B males (AH1 and AH2, 67 and 71 years old, respectively) whose HBV was transmitted from their wives with chronic HBV infection (CH1 and CH2, 67 and 66 years old, respectively). To clarify the characteristics of HBV quasispecies in such cases, we performed long-read deep sequencing of HBV preS1/preS2/S domain using samples from the 2 couples.
View Article and Find Full Text PDFAcetaminophen (APAP) is an over-the-counter (OTC) drug known worldwide for its safety and efficacy. However, in Japan, OTC drug overdose has become a prominent social problem in recent years due to stricter regulations for other drugs, especially among young people, and APAP is an increasing cause of acute liver injury due to overdose. This report describes three consecutive cases of acute liver failure in young women (22, 22 and 19 years old) due to APAP overdose in December 2023.
View Article and Find Full Text PDFObjective This study assessed the impact of dietary therapy and reduced body weight on the loss of skeletal muscle in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). Methods This was a single-center retrospective observational study. We enrolled 129 patients with MASLD who had undergone dietary therapy at our facility.
View Article and Find Full Text PDFBackground And Aims: Sarcopenia is associated with the prognosis of patients with liver cirrhosis and hepatocellular carcinoma (HCC). Given their diverse physiological activities, we hypothesized that plasma fatty acids might influence the progression of sarcopenia. This study aimed to clarify the association between fatty acids and sarcopenia in cirrhotic patients with HCC.
View Article and Find Full Text PDFArticle Synopsis
- - A 46-year-old Japanese man had a very high eosinophil count and elevated liver enzymes, leading to a diagnosis involving acute liver injury and deep vein thrombosis.
- - Imaging tests showed large clots in his femoral veins, and a liver biopsy indicated significant liver damage and inflammation.
- - Despite treatment with steroids and heparin, the patient suffered a cardiac arrest due to clots in his lungs and unfortunately passed away despite emergency interventions.
Article Synopsis
- Immune checkpoint inhibitors (ICIs), like durvalumab used for lung cancer, can cause immune-mediated hepatotoxicity (IMH), which sometimes does not respond to standard treatments like corticosteroids and mycophenolate mofetil (MMF).
- A case study involving a 69-year-old man with IMH after ICI treatment showed that despite initial therapy, his liver damage persisted, confirmed by liver histology showing CD8 + T cell infiltration.
- The addition of tacrolimus, which targets T-cell suppression, resulted in a rapid improvement in liver function, indicating that tacrolimus could be a viable treatment option for IMH cases that do not respond to traditional therapies when CD8 +
Duodenal varices are detected infrequently, and their rupture is very rare. We encountered an 87-year-old man who developed duodenal varices rupture during chemotherapy with atezolizumab and bevacizumab (ATZ/BV) for hepatocellular carcinoma. We identified massive bleeding of a ruptured varix in the horizontal portion of the duodenum with emergency esophagogastroduodenoscopy (EGD).
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