Discretizing low-intensity whole-body vibration into bouts with short rest intervals promotes bone defect repair in osteoporotic mice.

Continuous administration of low-intensity whole-body vibration (WBV) gradually diminishes bone mechanosensitivity over time, leading to a weakening of its osteogenic effect. We investigated whether discretizing WBV into bouts with short rest intervals was effective in enhancing osteoporotic bone repair. Ten-week-old female mice were ovariectomized and underwent drill-hole defect surgery (Day 0) on the right tibial diaphysis at 11 weeks of age.

Morphology of the Upper Esophageal Sphincter or Cricopharyngeus Muscle Revisited: A Study Using Adult and Fetal Specimens.

Histological examination of specimens from 22 donated elderly cadavers and 15 human fetuses revealed that the cricopharyngeus muscle (CPM) provided (1) posterior circular muscle fibers adjacent to the external aspect of the uppermost esophageal circular muscle and (2) a thin anterior sling connecting to that same muscle. Another thick lateral bundle of longitudinal muscle originated independently from a fascia covering the posterior cricoarytenoideus muscle, extended laterally and posteriorly, and occupied a space after the CPM had disappeared at the anterolateral angle of the esophagus below the cricoid. The thick fascia contained abundant elastic fibers along the internal surface of the pharyngeal constrictors (posteromedial elastic lamina), but was interrupted or discontinued near the cricoid origin of the CPM.

[Case of epicardial left ventricular pacing lead implantation under general anesthesia in a patient with severe cardiac dysfunction].

An 82-year-old man with severe cardiac dysfunction due to ischemic cardiac myopathy was diagnosed as indication for biventricular pacing. His left ventricular ejection fraction was 22%. Because of difficulty in coronary sinus lead fixation, epicardial lead implantation through a thoracotomy under general anesthesia was scheduled.

Comparative neurotoxicity of intrathecal and epidural lidocaine in rats.

Background: Although there is a considerable difference in the number of clinical reports of neurologic injury between spinal anesthesia and other regional techniques, there are no animal data concerning a difference in the local anesthetic neurotoxicity between intrathecal and epidural administration. In the current study, the functional and morphologic effects of lidocaine administered intrathecally and epidurally were compared in rats.

Methods: Male rats were implanted with an intrathecal or epidural catheter through L4-L5 vertebra in the caudal direction.

Pulmonary Doppler flow velocity pattern during caudal epidural anaesthesia in children.

Background: Haemodynamic effects of caudal anaesthesia in children have not been fully investigated. In the present study, we evaluated pulmonary haemodynamics during caudal anaesthesia in otherwise healthy children using Doppler-echocardiography.

Methods: Fifteen children undergoing elective lower abdominal surgery were randomly divided into two groups: nine children received 1.