Publications by authors named "Keila Velazquez-Arcelay"
Article Synopsis
- The migration of modern Eurasians from Africa involved interbreeding with Neanderthals and Denisovans, incorporating archaic DNA into their genomes, which may have helped adaptation to new environments.
- Research examined the evolution of circadian rhythms (chronotypes) by comparing gene sequences between archaic hominins and present-day humans, identifying differences in 28 circadian genes that could affect gene expression and regulation.
- The study found that archaic genetic variants are linked to chronotype traits, particularly favoring morningness, suggesting possible adaptations in response to higher latitudes, and highlighted specific genes with evidence of adaptive introgression.
Article Synopsis
- - The migration of modern Eurasians from Africa and interbreeding with Neanderthals and Denisovans led to the integration of archaic DNA into contemporary human genomes, possibly enhancing adaptation to different environmental factors in Eurasia.
- - Analysis of genomic data revealed significant differences in circadian genes between archaic hominins and modern humans, including specific gene variants that may influence chronotype (the natural preference for being active at certain times of day).
- - The study concludes that introgression from archaic hominins has likely played a role in shaping circadian gene regulation and influencing human chronotype, particularly favoring morningness, in response to adaptive pressures in high-latitude environments.
Background: Long-term balancing selection (LTBS) can maintain allelic variation at a locus over millions of years and through speciation events. Variants shared between species in the state of identity-by-descent, hereafter "trans-species polymorphisms", can result from LTBS, often due to host-pathogen interactions. For instance, the major histocompatibility complex (MHC) locus contains TSPs present across primates.
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