Mapping biomedical literature with WNT signaling pathway.

Epigenetic studies in cancer pathways have been essential in helping scientists understand the key players in cancer. Gene relationships reported in biomedical literature are valuable to understand the interaction network. Nevertheless, biomedical literature is growing rapidly and the scientific community needs a mechanism to have up-to-date pathways that reflect the new findings from the literature.

Large-scale CpG methylation analysis identifies novel candidate genes and reveals methylation hotspots in acute lymphoblastic leukemia.

This study examined DNA methylation associated with acute lymphoblastic leukemia (ALL) and showed that selected molecular targets can be pharmacologically modulated to reverse gene silencing. A CpG island (CGI) microarray containing more than 3,400 unique clones that span all human chromosomes was used for large-scale discovery experiments and led to 262 unique CGI loci being statistically identified as methylated in ALL lymphoblasts. The methylation status of 10 clones encompassing 11 genes (DCC, DLC-1, DDX51, KCNK2, LRP1B, NKX6-1, NOPE, PCDHGA12, RPIB9, ABCB1, and SLC2A14) identified as differentially methylated between ALL patients and controls was independently verified.