Publications by authors named "Keiko Yamamoto-Kabasawa"
Aims: Megalin, a proximal tubular endocytosis receptor, is excreted in urine in two forms: ectodomain (A-megalin) and full-length (C-megalin). We explored whether urinary megalin levels can be used as independent prognostic biomarkers in the progression of diabetic kidney disease (DKD).
Methods: The associations between baseline urinary A-megalin/creatinine (Cr) and/or C-megalin/Cr levels and the subsequent estimated glomerular filtration rate (eGFR) slope were analyzed using a generalized estimating equation.
Higher estimated net endogenous acid production with lower intake of fruits and vegetables based on a dietary survey is associated with the progression of chronic kidney disease.
BMC Nephrol
November 2019
Article Synopsis
- Dietary acid load may influence the progression of chronic kidney disease (CKD), but specific food associations are unclear.
- A study using a diet history questionnaire analyzed dietary habits among CKD patients to understand the impact of various foods on dietary acid load.
- Findings suggest that higher net endogenous acid production (NEAP) is linked to lower potassium and higher protein intake, and is associated with a greater decline in kidney function, while lower consumption of fruits and vegetables contributes to higher NEAP levels.
Article Synopsis
- Albuminuria is a key indicator of chronic kidney disease and associated risks of cardiovascular and all-cause mortality, with the need for minimizing urinary albumin highlighted regardless of disease status.
- A 12-week lifestyle modification program focusing on diet and exercise led to a significant reduction in urinary albumin:creatinine ratio (UACR) among 295 Japanese adults, including those with type 2 diabetes, metabolic syndrome, and hypertension, without negatively affecting kidney function (eGFR).
- The study found improvements in UACR were linked to decreased fasting plasma glucose levels and, in patients with hypertension, lower blood pressure, demonstrating the positive impact of lifestyle changes on these health metrics.
Objective: Megalin, an endocytic receptor in proximal tubule cells, is involved in the mechanisms of albuminuria in diabetic nephropathy (DN). To develop efficient novel biomarkers associated with the pathogenesis of DN, we investigated urinary megalin excretion in type 2 diabetes.
Research Design And Methods: Sandwich enzyme-linked immunosorbent assay systems were established with monoclonal antibodies against the NH(2) (amino [A]-megalin assay) and COOH (C-megalin assay) termini of megalin to analyze urinary forms of megalin in 68 patients with type 2 diabetes.
Expression and function of megalin, an endocytic receptor in proximal tubule cells (PTCs), are reduced in diabetic nephropathy, involved in the development of proteinuria/albuminuria. Lipopolysaccharide (LPS) is chronically increased in diabetic sera, by the mechanism called metabolic endotoxemia. We investigated low-level LPS-mediated signaling that regulates megalin expression in immortalized rat PTCs (IRPTCs).
View Article and Find Full Text PDF