Publications by authors named "Keiko Wan"
Article Synopsis
- Subcutaneous (SC) administration of the pneumococcal conjugate vaccine (V114) is standard for infants in Japan, while intramuscular (IM) administration is used elsewhere; this study compares the two routes' safety and immune responses.
- In a study with 133 healthy Japanese infants, the rates of adverse events like irritability and fever were similar between SC and IM groups, but IM administration had lower irritability and injection-site reactions.
- Overall, the findings indicate that IM administration of V114 could be a viable vaccination option for infants in Japan, with comparable immune responses to SC administration.
This Phase I study evaluated the safety, tolerability, and immunogenicity of V114, a 15-valent pneumococcal conjugate vaccine (PCV), via subcutaneous (SC) or intramuscular (IM) administration, in healthy Japanese infants 3 months of age. A total of 133 participants were randomized to receive four doses (3 + 1 regimen) of V114-SC ( = 44), V114-IM ( = 45), or 13-valent PCV (PCV13)-SC ( = 44) at 3, 4, 5, and 12-15 months of age. Diphtheria, tetanus, and pertussis-inactivated poliovirus (DTaP-IPV) vaccine was administered concomitantly at all vaccination visits.
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