Nodular hepatic lesion mimicking gallbladder carcinoma in myeloma.

An 81-year-old man was diagnosed with nodular hepatic lesion of extramedullary plasmacytoma with the absence of FDG uptake. Doppler ultrasonography showed pulsations and abundant blood flow signals within the tumor. The blood flow was temporally reduced after daratumumab-based induction therapy; however, the tumor rapidly re-expanded with blood reflow.

Influence of iron-saturation of plasma transferrin in iron distribution in the brain.

Based on the evidence that iron distribution in the peripheral tissues is changed by iron-saturation of plasma transferrin, the influence of iron-saturation of plasma transferrin in iron delivery to the brain was examined. Mouse plasma was pre-incubated with ferric chloride in citrate buffer to saturate transferrin and then incubated with (59)FeCl(3). Peak retention time of (59)Fe was transferred from the retention time of transferrin to that of mercaptalbumin, suggesting that iron may bind to albumin in the plasma in the case of iron-saturation of transferrin.

Abnormal iron delivery to the bone marrow in neonatal hypotransferrinemic mice.

Hypotransferrinemic (HP) mice have a splicing defect in the transferrin gene, resulting in < 1% of the normal plasma levels of transferrin. They have severe anemia, suggesting that transferrin is essential for iron uptake by erythroid cells in the bone barrow. To clarify the significance of transferrin on iron delivery to the bone marrow, iron concentration and 59Fe distribution were determined in 7-day-old HP mice.