Publications by authors named "Keiko Igarashi"
Objective: We investigated the antibody titer of spike-specific immunoglobulin G (IgG) antibodies after receiving coronavirus repair uridine ribonucleic acid (RNA) vaccine (BNT162b2, Pfizer) in health care workers.
Methods: At one hospital, health care workers received the vaccination between February and May 2021. A survey using questionnaires and spike-specific IgG antibody tests (Abbott) was conducted in 293 participants who had been vaccinated at least once and consented to this study at the time of medical checkups between April and May 2021.
Mucinous gastric carcinoma (MGC) is a unique subtype of gastric cancer with a poor survival outcome. Comprehensive molecular profiles and putative therapeutic targets of MGC remain undetermined. We subjected 16 tumour-normal tissue pairs to whole-exome sequencing (WES) and an expanded set of 52 tumour-normal tissue pairs to subsequent targeted sequencing.
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- Nrf2 activation can help protect against cancer in animal models by promoting detoxification, but mutations in Nrf2 can also make human cells more aggressive by enhancing tumor growth.
- In a study using mice with high Nrf2 levels, it was found that these mice had fewer and smaller urethane-induced tumors due to improved detoxification of the chemical.
- However, when cancer cells from these mice were transplanted, they showed increased tumor growth, indicating that while Nrf2 activation can aid in cancer prevention, it may also boost the aggressiveness of established tumors, highlighting its complex role in cancer progression.