Publications by authors named "Keiji Ikawa"
Activated neutrophils produce serine proteases, which activate cells through protease-activated receptor 2 (PAR2). As proteinase 3 (PR3) induces the secretion of interleukin (IL)-18 from epithelial cells in combination with lipopolysaccharide (LPS) in vitro, we examined whether neutrophils, serine proteases, and PAR2 are involved in the induction of serum IL-18 and IL-18-dependent liver injury in mice treated with heat-killed Propionibacterium acnes and LPS. LPS-induced serum IL-18 levels in P.
View Article and Find Full Text PDFArticle Synopsis
- Human salivary glands produce CD14, an innate immunity molecule, and secrete it into saliva, with concentrations highest in parotid saliva compared to whole saliva and serum.
- Exposure to the bacteria Actinobacillus actinomycetemcomitans leads to increased IL-8 production in oral epithelial cells, which is further enhanced by whole and parotid saliva, although saliva alone doesn't induce IL-8.
- Parotid saliva shows antibacterial properties against the bacteria, and the presence of CD14 is crucial for its invasion into cells and the resulting IL-8 production, highlighting its role in oral immune response.