Publications by authors named "Keiji Adachi"
Raman spectroscopy was applied to study the structural differences between herpes simplex virus Type I (HSV-1) and Epstein-Barr virus (EBV). Raman spectra were first collected with statistical validity on clusters of the respective virions and analyzed according to principal component analysis (PCA). Then, average spectra were computed and a machine-learning approach applied to deconvolute them into sub-band components in order to perform comparative analyses.
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- This study investigated how outer-membrane vesicles (OMVs) from oral bacteria influence the degeneration of neuroblastoma cells, specifically using in situ Raman spectroscopy to track metabolomic changes.
- OMVs are associated with Alzheimer's disease (AD) as they deliver harmful toxins that can damage neurons, but the exact chemical processes involved are not well understood.
- The research revealed important chemical signatures and mechanisms related to neuronal degradation, including the roles of lipopolysaccharides and proteins involved in forming amyloid plaques and Tau tangles that worsen AD symptoms.
Objectives: Placement of a denture results in the application of mechanical stress (MS), such as occlusal force, onto the oral mucosa beneath the denture. To better understand the molecular mechanism underlying MS-induced inflammation in the oral mucosa, we examined the impact of MS on human oral epithelial cells (HO-1-N-1) and human fibroblasts (HGFs) in this study.
Materials And Methods: MS was applied on HO-1-N-1 and HGFs using a hydrostatic pressure apparatus.
Background: Helicobacter pylori (H. pylori) colonize the stomach and are considered an etiological agent of gastric cancer. The oral cavity is a transmission route to the stomach, but the exact site of colonization has not yet been explicated.
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