Fracture resistance of CAD/CAM restorative materials in mismatched removable partial denture rests: An in vitro experimental and finite element analysis.

To evaluate the fracture resistance of computer-aided design and computer-assisted manufacturing restorations as the abutment of removable partial dentures, experimental blocks, with the rest seat made of feldspar, hybrid resin composite, lithium disilicate glass ceramic, or zirconia, were subjected to loading by a metallic occlusal rest. The rest contacted the rest seat with an accurate fit and two mismatch contact conditions: bottom and sidewall contact. Zirconia exhibited the highest fracture load, and the fracture load of the accurate fit was significantly higher than that of the sidewall contact (p<0.

Accessory breast cancer in the inframammary region: a case report and review of the literature.

Background: Although a few cases of accessory breast cancer (ABC) have been reported, most were in the axillary region. We encountered an extremely rare case of ABC in the inframammary region (IMR).

Case Presentation: The patient was a 68-year-old postmenopausal woman who had noticed a congenital accessory nipple in her left IMR with slight, occasional discharge 20 years ago.

Influence of the Covering Area of Major Connectors of Mandibular Dentures on the Accuracy of Speech Production: A Pilot Study.

Background/objectives: Speech impairment during the initial phase of removable partial denture (RPD) treatment can prevent patient adaptation to RPDs. This quasi-experimental study aimed to investigate the influence of the covering area of major connectors located in the mandibular anterior region on the accuracy of speech production.

Methods: Fifteen adults (12 men and 3 women aged 26-40 years) with healthy dentition were recruited.

Lipopolysaccharides induced increases in Fas ligand expression by Kupffer cells via mechanisms dependent on reactive oxygen species.

Fas-Fas ligand (FasL)-dependent pathways exert a suppressive effect on inflammatory responses in immune-privileged organs. FasL expression in hepatic Kupffer cells (KC) has been implicated in hepatic immunoregulation. In this study, modulation of FasL expression of KC by endogenous gut-derived bacterial LPS and the role of reactive oxygen species (ROS) as potential mediators of FasL expression in KC were investigated.

Biliary obstruction reduces hepatic killing and phagocytic clearance of circulating microorganisms in rats.

Septic complications are common in patients with biliary obstruction. This is thought to be related, in part, to dysfunction of the hepatic reticuloendothelial system (RES). It has been reported that nearly 80% of circulating microorganisms are phagocytosed and killed within the liver and that clearance of circulating pathogens is significantly impaired in patients with jaundice.

Hepatic allograft-derived Kupffer cells regulate T cell response in rats.

In liver transplantation, the development of tolerance is associated with an increased rate of apoptosis of T lymphocytes in the portal inflammatory infiltrate and the presence of an intragraft Th2-like T cell population. Underlying mechanisms are poorly understood. Kupffer cells (KC), which reside in the hepatic sinosoids, can directly interact with circulating T lymphocytes and thus are uniquely positioned to play a role in immunomodulation.

Clinical significance of circulating tumor cells in blood by molecular detection and tumor markers in esophageal cancer.

Background: The clinical significance of circulating tumor cells in the blood during surgery has not been elucidated in esophageal squamous cell carcinoma (ESCC). We evaluated the relationship between circulating tumor cells and clinicopathologic findings, compared with that of serum squamous cell carcinoma (SCC) antigen and carcinoembryonic antigen (CEA), in ESCC.

Methods: Blood samples from 54 consecutive patients were obtained from the peripheral artery and the superior vena cava at three points in time: immediately before surgery, and before and after tumor resection.

Perioperative detection of circulating cancer cells in patients with colorectal hepatic metastases.

Background/aims: Surgical resection is the most effective therapy for metastatic colorectal cancer to the liver. However, the selection criteria for patients who may benefit from partial hepatectomy are not fully defined. The aim of this study was to evaluate the usefulness of perioperative molecular detection of circulating cancer cells in predicting clinical outcome in patients with colorectal metastatic liver cancer.

Intraoperative molecular detection of circulating tumor cells by reverse transcription-polymerase chain reaction in patients with biliary-pancreatic cancer is associated with hematogenous metastasis.

Background: Circulating tumor cells in the blood were frequently detected by reverse transcription-polymerase chain reaction during operation in patients with biliary-pancreatic cancer. We investigated the relationship between circulating tumor cells during operation and hematogenous metastases.

Methods: Blood samples from 67 patients with biliary-pancreatic cancer were obtained from the portal vein, peripheral artery, and superior vena cava during operation.