Anti-tumor activity of a recombinant measles virus against canine lung cancer cells.

Canine primary lung cancer with metastasis has a poor prognosis with no effective treatment. We previously generated a recombinant measles virus (MV) that lost binding affinity to a principal receptor, SLAM, to eliminate its virulence as a new cancer treatment strategy. The virus, rMV-SLAMblind, targets nectin-4, recently listed as a tumor marker, and exerts antitumor activity against nectin-4-positive canine mammary cancer and urinary bladder transitional cell carcinoma cells.

Glucoregulatory factors in canine hepatocellular carcinoma and leiomyosarcoma with non-islet cell tumour hypoglycaemia.

Introduction: Hypoglycaemia caused by malignant tumours other than insulinoma is referred to as non-islet cell tumour hypoglycaemia (NICTH), which may be caused by hepatocellular carcinoma (HCC) and leiomyosarcoma (LMS) in veterinary medicine. However, the pathogenetic mechanism of NICTH remains unclear. Therefore, this study aimed to evaluate the gene-expression levels of glucoregulatory factors in canine HCC and LMS accompanied by hypoglycaemia.

Effect of different contrast medium injection protocols for analysis of hepatic computed tomography perfusion in healthy dogs.

Objective: To evaluate the hepatic CT perfusion (CTP) for determining the appropriate protocol for the dual-input maximum-slope model in dogs.

Animals: 5 healthy dogs.

Procedures: Each dog underwent CTP with different contrast medium administration protocols.

Serum vascular endothelial growth factor in dogs with various proliferative diseases.

Angiogenesis plays an important role in the proliferation and metastasis mechanisms of malignant tumors. Vascular endothelial growth factor (VEGF), a group of cytokines that contribute to angiogenesis and vasculogenesis. This study aimed to investigate the serum VEGF-A concentrations in dogs with various proliferative diseases.

Comparison of outcomes between medical and surgical treatment in dogs with prostatic adenocarcinoma: a retrospective study.

Background: Prostatic cancer is uncommon in dogs. Dogs with prostatic carcinoma have been reported to have a poor prognosis. Information regarding prognosis with various surgery options as well as prognosis with surgical vs.

Neutrophilic leucocytosis induced by granulocyte colony-stimulating factor and interleukin-6 in canine primary lung adenocarcinoma.

Background: Neutrophilic leucocytosis as a paraneoplastic syndrome may occur in dogs with lymphoma, renal carcinoma, rectal polyps and metastatic fibrosarcoma. However, the information on canine lung adenocarcinoma with neutrophilic leucocytosis is lacking.

Objective: This study aimed to describe the clinical features and cytokine profiles of canine patients with primary lung adenocarcinoma and neutrophilic leucocytosis.

Antitumor activity of an oncolytic measles virus against canine urinary bladder transitional cell carcinoma cells.

The prognosis of canine transitional cell carcinoma (TCC) of urinary bladder is generally poor because it is difficult to diagnose at early stages and conventional therapies, such as surgical resection and/or chemotherapy, are often not curative treatments. Based on our previous report that recombinant measles virus (rMV-SLAMblind) therapy could be a new treatment for canine mammary tumor, the applicability of rMV-SLAMblind in canine urinary bladder TCC was examined in this study. A canine TCC cell line was established from a TCC patient dog by transplanting a piece of the tumor mass into an immunodeficient mouse and then isolating the primary TCC cells from the grown tumor mass.

Computed tomographic-derived measurements of shunt fraction and hepatic perfusion in dogs with a single extrahepatic portosystemic shunt in a clinical setting.

Objective: To evaluate the clinical feasibility and usefulness of measuring shunt fraction (SF) and hepatic perfusion with CT in dogs with a single extrahepatic portosystemic shunt (EPSS).

Animals: 36 client-owned dogs with EPSS.

Procedures: Dogs with EPSS referred for treatment between February 2016 and May 2017 were eligible for the clinical trial.

Inhibition of growth of canine-derived vascular endothelial cells by non-steroidal anti-inflammatory drugs and atrial natriuretic peptide.

This study investigated the direct effects of non-steroidal anti-inflammatory drugs (NSAIDs) and atrial natriuretic peptide (ANP) on canine-derived vascular endothelial cells (VECs). VECs were isolated and cultured from canine arteries and veins. The mRNA expressions of vascular endothelial growth factor receptor 2, cyclooxygenase-2, and natriuretic peptide receptor 1 were detected in the cultured VECs.

Omnifocus laparoscope.

The depth of focus of the latest-model "Chip-on-the-Tip" laparoscopes is limited to 10 cm. The proposed omnifocus laparoscope stretches this depth of focus to 160 cm. The proposed laparoscope is omnifocus, which means that all spots in the picture are in focus, not just certain designated spots as in autofocus devices.

Surface imaging using a noncontact divergence-ratio axi-vision camera profilometer for laparoscopic and endoscopic applications.

Images from ordinary laparoscopes and endoscopes are two dimensional (2D), meaning the surgeon's depth perception is hindered. The proposed method supplements the 2D image with an image of the depth profile of the surface. The depth profile is obtained in real time without surface contact.

Super deep 3D images from a 3D omnifocus video camera.

When using stereographic image pairs to create three-dimensional (3D) images, a deep depth of field in the original scene enhances the depth perception in the 3D image. The omnifocus video camera has no depth of field limitations and produces images that are in focus throughout. By installing an attachment on the omnifocus video camera, real-time super deep stereoscopic pairs of video images were obtained.

Omnifocus video camera.

The omnifocus video camera takes videos, in which objects at different distances are all in focus in a single video display. The omnifocus video camera consists of an array of color video cameras combined with a unique distance mapping camera called the Divcam. The color video cameras are all aimed at the same scene, but each is focused at a different distance.

Three-dimensional laparoscope based on the manipulation of polarized light by a cellophane half-wave plate.

A three-dimensional laparoscope that can capture three-dimensional images during surgery is reported. The principle is solely based on the manipulation of polarized light by a cellophane half-wave plate rather than computer processing; hence there is no time delay (it operates in real time) and lesions are viewed in true color, which is important for diagnostics. Three-dimensional images are obtained with a single laparoscope.

Three-dimensional camera phone.

An inexpensive technique for realizing a three-dimensional (3D) camera phone display is presented. Light from the liquid-crystal screen of a camera phone is linearly polarized, and its direction of polarization is easily manipulated by a cellophane sheet used as a half-waveplate. The novel 3D camera phone display is made possible solely by optical components without resorting to computation, so that the 3D image is displayed in real time.

Gain-modulated Axi-Vision Camera (high speed high-accuracy depth-mapping camera).

We describe a novel real-time depth-mapping camera, the Gainmodulated Axi-Vision Camera, where pulsed laser light is combined with a gain-modulated camera. Depth resolution of 2.4 mm was obtained, which is higher than the resolution of the previously reported depth-mapping Axi- Vision Camera.

High-definition real-time depth-mapping TV camera: HDTV Axi-Vision Camera.

We have developed a field-worthy, high-definition, real-time depth-mapping television camera called the HDTV Axi-Vision Camera. The camera can simultaneously capture both an ordinary HDTV color image and a depth image of objects on more than 1280 x 720 pixels at a frame rate of 29.97 Hz, or on 853 x 480 pixels at a frame rate of 59.