Immune Checkpoint Inhibitor Therapy for Patients With Non-small Cell Lung Cancer Ineligible for Platinum Doublet Chemotherapy.

Background/aim: Combined therapy with immune checkpoint inhibitors plus platinum doublet chemotherapy has a survival advantage over platinum doublet chemotherapy in patients with non-small cell lung cancer. However, a variety of factors make it difficult to administer treatment with platinum doublet chemotherapy in many patients in clinical practice and there are few reports on the efficacy and safety of first-line treatments with immune checkpoint inhibitors for patients who are ineligible for platinum doublet chemotherapy. This observational study aimed to evaluate the efficacy and safety of first-line immune checkpoint inhibitor therapy for this population.

Temporal Prediction Signals for Periodic Sensory Events in the Primate Central Thalamus.

Prediction of periodic event timing is an important function for everyday activities, while the exact neural mechanism remains unclear. Previous studies in nonhuman primates have demonstrated that neurons in the cerebellar dentate nucleus and those in the caudate nucleus exhibit periodic firing modulation when the animals attempt to detect a single omission of isochronous repetitive audiovisual stimuli. To understand how these subcortical signals are sent and processed through the thalamocortical pathways, we examined single-neuron activities in the central thalamus of two macaque monkeys (one female and one male).

Two new species of erect Bryozoa (Gymnolaemata: Cheilostomata) and the application of non-destructive imaging methods for quantitative taxonomy.

Two new species of cheilostome Bryozoa are described from continental-slope habitats off Mauritania, including canyon and cold-water coral (mound) habitats. Internal structures of both species were visualised and quantified using microcomputed tomographic (micro-CT) methods. Cellaria bafouri n.

Bryozoans from RV Sonne deep-sea cruises SO 167 'Louisville' and SO 205 'Mangan'.

The German research vessel Sonne is operating in the Pacific, Southern and Indian Oceans. In the current stage of development in Pacific deep-sea mining projects, prior understanding of biodiversity patterns in the affected regions is one of the major research goals of the RV Sonne cruises. In the present study, nine bryozoan species are reported from the Equatorial East Pacific and the Kermadec-Tonga Ridge, collected during RV Sonne cruises SO 167 "Louisville" and SO 205 "Mangan", from 356-4007 m.