Publications by authors named "Kei Konishi"
Rabies is a fatal neurological disorder caused by rabies virus (RABV) infection. Approximately 60,000 patients die from rabies annually, and there are no effective treatments for this disease. Nucleoside analogs are employed as antiviral drugs based on their broad antiviral spectrum, and certain nucleoside analogs have been reported to exhibit anti-RABV activity.
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- - The study investigates the effectiveness of monotherapy with oral antiviral ensitrelvir and the anti-inflammatory corticosteroid methylprednisolone, as well as their combination, in treating hamsters infected with SARS-CoV-2, focusing on timing and therapeutic outcomes.
- - Results showed that combining ensitrelvir and methylprednisolone significantly improved respiratory health and decreased pneumonia risk, even when treatment started two days post-infection, by reducing lung damage and inflammation.
- - The findings underscore the potential benefits of using a combination therapy of antiviral and corticosteroid drugs for better lung pathology and inflammatory response management in COVID-19 cases, including those caused by the delta and omicron variants.
Utility of whole brain radiation therapy for leptomeningeal carcinomatosis.
Int J Clin Oncol
July 2020
Background: Although whole brain radiation therapy (WBRT) is commonly used as first-line treatment for leptomeningeal carcinomatosis, the prognosis is uncertain despite treatment. Moreover, the benefit of WBRT for leptomeningeal carcinomatosis has not been adequately evaluated. Therefore, this study aimed to clarify the utility of WBRT for leptomeningeal carcinomatosis.
View Article and Find Full Text PDFBackground: Primary testicular lymphoma (PTL) is a rare, extranodal lymphoma that often relapses in the contralateral testis. We evaluated outcomes in patients with any stage of PTL who had received CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone) with rituximab chemotherapy and prophylactic radiotherapy to the contralateral testis.
Methods: We retrospectively identified 15 patients (median age 66 years; range 39-81) diagnosed with diffuse large B-cell PTL in the period 2000-2014.
Background: In Japan, there are still no reports of long-term outcome for hypofractionated radiotherapy to the whole breast after breast-conserving surgery (BCS). We report our institution's results from evaluation of the efficacy and safety of hypofractionated radiotherapy for Japanese women.
Methods: Data in the medical records of 327 patients were retrospectively reviewed.