Publications by authors named "Kei Kijima"
Validity evaluation of a rat model of monoiodoacetate-induced osteoarthritis with clinically effective drugs.
BMC Musculoskelet Disord
November 2024
Background: Knee osteoarthritis (KOA) is the most common type of joint disease in elderly people and is characterized by pain and dysfunction. Although the monoiodoacetate (MIA)-induced model is widely used as a rodent KOA model, it is important to acknowledge the inherent limitations of this model, as the MIA model develops complex pathological phases on a daily basis. An accurate understanding of this model and the selection of an appropriate time point according to the target for drug candidates can lead to the development of clinically effective drugs.
View Article and Find Full Text PDFWe encountered a case of spontaneous thymic carcinosarcoma in a young Crl:CD (Sprague Dawley) rat. Grossly, a white multinodular mass replaced the thymus in the thoracic cavity. Histologically, multiple nodules were separated by fibrous stroma, and each nodule included isolated regions that were composed of epithelial or non-epithelial tumor cells.
View Article and Find Full Text PDFArticle Synopsis
- An 82-year-old woman with primary biliary cholangitis developed irreversible neurological issues due to metronidazole (MNZ), a common antibiotic.
- While MNZ-induced encephalopathy is typically reversible, it can lead to severe complications or even death in rare instances.
- Doctors should exercise caution when prescribing medications, especially for patients needing high doses over long periods or those with liver problems.