Publications by authors named "Kei Hagiwara"
Background: The risk of mortality due to serious complications associated with hepatectomy for biliary tract cancer remains high. We aimed to investigate the significance of preoperative functional liver volume in predicting and preventing serious morbidity following hepatectomy with bile duct resection (BDR).
Methods: Seventy-one patients who underwent hepatectomy with BDR for biliary tract cancer were included.
Purpose: This study investigated the significance of the Global Leadership Initiative on Malnutrition (GLIM) for patients with resected biliary tract cancers.
Methods: The subjects of this retrospective analysis were 114 patients who underwent radical surgery for cholangiocarcinoma between 2018 and 2023. We analyzed both handgrip force and skeletal muscle area and classified patients as having GLIM malnutrition or modified GLIM malcondition.
Article Synopsis
- Atomoxetine, a medication for ADHD, can cause serious cardiac complications if overdosed, leading to cases like the one presented here involving venoarterial extracorporeal membrane oxygenation (VA-ECMO) for life-threatening cardiogenic shock.
- A 30-year-old male experienced seizures and severe circulatory failure after a significant atomoxetine overdose, requiring emergency VA-ECMO for resuscitation, alongside other treatments like medication removal and intravenous lipid emulsion.
- The case highlights the need for healthcare providers to be aware of the potentially severe cardiac effects of atomoxetine overdose and underscores the importance of close monitoring and intensive care for patients in critical condition.
Aim: Laparoscopic segmentectomy (LS) using indocyanine green (ICG) fluorescence navigation with negative staining method has potential for performing accurate and safe anatomical excision. This study aimed to evaluate the significance of LS using ICG fluorescence navigation compared with open segmentectomy (OS).
Methods: Eighty-seven patients who underwent anatomical segmentectomies were evaluated for OS ( = 44) and LS ( = 43).
Article Synopsis
- Microvascular invasion (MVI) significantly influences postoperative outcomes in patients with small hepatocellular carcinoma (HCC) (≤ 3 cm), making its prediction essential for treatment decisions.
- A study analyzed 129 patients to identify MVI predictors, revealing that factors like AFP-L3, PIVKA-II, and metabolic tumor volume (MTV) are strong indicators.
- A scoring system based on these factors showed high accuracy in predicting MVI, enabling better treatment strategies for small HCC cases.*
Aims: This study aimed to determine the value of the drainage fluid volume and direct bilirubin level for predicting significant bile leakage (BL) after hepatectomy and establish novel criteria for early drain removal.
Methods: Data from 351 patients who underwent hepatic resection at Gunma University in Japan between October 2018 and March 2022 were retrospectively analyzed. Clinical characteristics and surgical outcomes of patients with and without significant BL were compared.
Background: There are few studies that examined the relationship between preoperative zinc (Zn) concentrations and postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP).
Methods: Data from 98 patients who underwent DP between January 2016 and April 2022 were retrospectively reviewed. Patients' clinicopathological and surgical outcomes were analyzed, and we examined the relationship between Zn and clinically relevant POPF (CR-POPF) after DP.
Background: Sarcopenia is a poor prognostic factor in cancer patients. In recent years, there have been reports that serum creatinine and cystatin C (Cr/CysC) ratio is associated with sarcopenia. However, the prognostic value of the Cr/CysC ratio in biliary tract cancer is unclear.
View Article and Find Full Text PDFIncreasing evidence suggests that nutritional indices, including the geriatric nutritional risk index (GNRI) and prognostic nutritional index (PNI), are predictors of poor prognosis in patients with hepatocellular carcinoma (HCC). Hence, this study aimed to explore the value of the GNRI and PNI in evaluating postoperative prognosis in patients with HCC, particularly regarding its recurrence patterns. We performed a retrospective analysis of 203 patients with HCC who underwent initial hepatic resection.
View Article and Find Full Text PDFPurpose: Pancreatoduodenectomy (PD) is a highly invasive procedure. Intra-abdominal infections and pancreatic fistulas are strongly correlated complications. In the present study, we identified the risk factors for postoperative early drain colonization (POEDC) and established a perioperative management strategy.
View Article and Find Full Text PDFArticle Synopsis
- FibCare is a new testing device designed to quickly measure fibrinogen levels in patients, and this study aimed to evaluate its accuracy in an emergency department setting.* -
- The study analyzed blood samples from 147 patients and found that while FibCare and the traditional Clauss method had a moderate correlation in results, FibCare missed a significant number of hypofibrinogenemia cases.* -
- The findings suggest that although FibCare is compatible with existing methods, healthcare providers should be cautious of its potential to underestimate fibrinogen levels, particularly in trauma patients and severe cases.*
Article Synopsis
- * M2BPGi, secreted by cancer-associated fibroblasts, enhances the growth and invasion of PC cells, independent of galectin-3 suppression.
- * Reducing M2BPGi levels in mice with PC led to smaller tumors and increased effectiveness of the chemotherapy drug gemcitabine, suggesting it could be a new treatment approach for PC.
Background: The recurrence rate after curative resection for hepatocellular carcinoma (HCC) reaches over 70% after 5 years and early recurrence (within 1 year) is now recognized as having a poor prognosis and has limited treatment options.
Methods: We retrospectively reviewed 184 consecutive patients who underwent curative hepatic resection for HCC. Severe early recurrence was defined as multiple (beyond up-to-7) liver recurrence or distant metastasis after hepatic resection within 1 year.
Article Synopsis
- RNF31 is a protein involved in inflammatory diseases and cancers, functioning as a key part of a complex that activates the NF-κB signaling pathway.
- In hepatocellular carcinoma (HCC), high levels of RNF31 are linked to poorer survival outcomes, as demonstrated through various tests and experiments.
- Knocking down RNF31 or using a specific inhibitor reduces HCC cell growth and invasion by blocking the NF-κB pathway, indicating that RNF31 could be a valuable therapeutic target.
Article Synopsis
- Chyle leakage (CL) is a common issue after pancreatic surgery, and lymphangiography can be a treatment option when other methods fail.
- A study examined 283 patients, finding that 10.2% experienced CL, with certain risk factors identified like malignant disease and fluid volume post-surgery.
- Results showed that lymphangiography significantly reduced the recovery time for CL without any adverse effects, indicating it is a safe and effective treatment.
Liver regeneration after hepatectomy is significantly suppressed in a muscular atrophy mouse model.
J Hepatobiliary Pancreat Sci
March 2024
Background: Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength. As reported in previous studies, the loss of skeletal muscle mass is associated with poor liver regeneration after hepatectomy. It is considered important to clarify the effect of sarcopenia on liver regeneration; however, there are no reports about model animals for sarcopenia.
View Article and Find Full Text PDFBackground: Fibrolamellar hepatocellular carcinoma (HCC) (FL-HCC) is rare in Japan. FL-HCC develops in young patients with no history of cirrhosis and tends to manifest lymphatic metastasis with clinical features similar to those of HCC. We present a case of FL-HCC in a young male patient.
View Article and Find Full Text PDFHepatocellular carcinoma (HCC) is a life-threatening complication of hemophilia. Reports of patients with hemophilia undergoing hepatectomy for HCC are scarce. We report the cases of patients with hemophilia A and B who underwent laparoscopic hepatectomy for HCC.
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- This study investigated the effectiveness of the serum creatinine/cystatin C (Cr/CysC) ratio as a prognostic indicator for patients with pancreatic cancer who underwent surgery.
- The analysis involved 88 patients and identified a Cr/CysC cutoff value of 1.05; lower ratios were linked to poorer outcomes, longer hospital stays, and were more prevalent in females and those with higher C-reactive protein levels.
- Overall, the Cr/CysC ratio appears to be a valuable tool for predicting survival and relapse-free intervals in pancreatic cancer patients after surgery.
Article Synopsis
- The study investigates the importance of defining malnutrition using the GLIM criteria in patients undergoing liver surgery for hepatocellular carcinoma (HCC), highlighting its relevance in various medical conditions including cancer and chronic diseases.
- Out of 174 patients reviewed, malnutrition was identified in 26.7% under GLIM criteria and 11.9% under modified GLIM criteria, with both definitions linked to worse liver function and tumor behavior.
- The modified GLIM criteria, which include handgrip strength and skeletal muscle area, were found to be better predictors of postoperative complications and survival rates, suggesting that nutritional and exercise strategies should be prioritized for malnourished patients with compromised liver health.
Background: Pancreatic cancer has an extremely poor prognosis and is one of the most chemoresistant cancers. Targeting cancer cell transcriptional complexes may enhance chemotherapy effectiveness. RNA-polymerase I (Pol-I)-mediated transcription is an essential initial step for ribosome biogenesis and is related to cancer cell proliferation.
View Article and Find Full Text PDFBackground/aim: Theoretically, laparoscopic procedures reduce the incidence of surgical site infection (SSI) compared with open surgery. This study aimed to investigate whether laparoscopic liver resection (LLR) attenuates organ-space SSI compared with open liver resection (OLR) using propensity score-matched (PSM) analysis.
Patients And Methods: This study included 530 patients who underwent liver resection as the original cohort.
Background: Chemotherapy for colorectal liver metastasis (CRLM) has improved dramatically over the past few decades. However, sinusoidal obstruction syndrome (SOS) induced by oxaliplatin leads to increased severe morbidity after hepatectomy for CRLM. Autotaxin is a novel liver fibrosis marker known to be taken up and metabolized by sinusoidal endothelial cells.
View Article and Find Full Text PDFBackground/aim: The relationship between body composition including skeletal muscle and liver hypertrophy initiated by portal vein embolization (PVE) for major hepatectomy has not been clarified. This study aimed to investigate the effects of skeletal muscle, body adipose, and nutritional indicators on liver hypertrophy.
Patients And Methods: Fifty-nine patients who underwent PVE scheduled for major right-sided hepatectomy were included.
Background/aim: This study aimed to identify the potential risk for postoperative pancreatic fistula (POPF), a major complication of pancreaticoduodenectomy.
Patients And Methods: This retrospective study included 124 patients with biliary and pancreatic disorders who underwent pancreaticoduodenectomy between 2015 and 2020. Bone marrow density (BMD) was determined in the 11th thoracic vertebra using preoperative computed tomographic images.