The Inhibition by Guanfu Base A of Neuropathic Pain Mediated by P2Y Receptor in Dorsal Root Ganglia.

Activation of satellite glial cells (SGCs) in the dorsal root ganglia (DRG) is involved in mechanical and thermal hyperalgesia. The upregulated P2Y receptor expressed in SGCs of the DRG participates in the nociceptive transmission of neuropathic pain. Guanfu base A (GFA) has been reported to exhibit antiarrhythmic and anti-inflammatory effects.

Increased sympathoexcitatory reflex induced by myocardial ischemic nociceptive signaling via P2X2/3 receptor in rat superior cervical ganglia.

The restructuring of cardiac innervation after myocardial ischemic injury, which is often associated with an increased sympathoexcitatory reflex characterized by an increase in blood pressure and sympathetic nerve activity. This study observed whether P2X(2/3) receptor in rat superior cervical ganglion (SCG) played a role in the increased sympathoexcitatory reflex induced by myocardial ischemic nociceptive signaling. The findings showed that the systolic blood pressure, heart rate and respiration in the myocardial ischemic rats were higher than those in control rats.

[Quantification of pentoxyverine citrate in human plasma by LC-ESI/MS method and its application].

A rapid and sensitive liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI/ MS) method for quantification of pentoxyverine citrate in human plasma has been developed and applied for the bioequivalence and pharmacokinetics study. After extracted from plasma samples with ethyl acetate, analysis was performed in selected ion monitoring (SIM) mode with a positive electrospray ionization (ESI) interface with a mobile phase consisted of methanol and water (0.4% glacial acetic acid and 4 mmol x L(-1) ammonium acetate, 43 : 57, v/v).

Effect of tetramethylpyrazine on DRG neuron P2X3 receptor involved in transmitting pain after burn.

Unlabelled: A burn is a severe injury, and the resulting pain can be very significant. Currently, opioids are the primary method of pain management, but these drugs have side effects; thus, it is of prime focus to research the mechanisms of pain formation and analgesic drugs.

Objective: To investigate the effects of tetramethylpyrazine (TMP) on burn pain mediated by the P2X3 receptor.

Expressions of P2X2 and P2X3 receptors in rat nodose neurons after myocardial ischemia injury.

The role of ATP is as a functional neurotransmitter and local intercellular signaling molecule. The nodose neurons express both P2X(2) and P2X(3) subunits in their plasma membrane. This study wants to observe the expression of P2X(2) receptor and the expression relationship between P2X(2) and P2X(3) in nodose neurons after myocardial ischemic injury.