Relationship Between Hematologic Inflammatory Markers and Glycemic Control in Type 2 Diabetes Mellitus Patients in a Tertiary Hospital in Nigeria.

Introduction: Hematologic inflammatory biomarkers derived from a full blood count (FBC) are elevated in Type 2 diabetes mellitus (DM). In low- and middle-income countries like Nigeria, a FBC is an affordable and easily available test, even in rural areas. Glycated hemoglobin (HbA1c), a measure of glycemic control, has been found to correlate with hematologic inflammatory markers.

Assessing Iron Status in Chronic Heart Failure Patients by Using Serum Ferritin and Transferrin Saturation Levels: A Cross-Sectional Descriptive Study.

Background and objective Chronic heart failure (HF) is a major medical condition worldwide and is associated with significant morbidity and mortality. Chronic HF could be complicated by iron deficiency (ID), and in severe cases, ID anemia, leading to negative HF outcomes even in people on optimal HF treatments. ID has been reported to be the most common nutritional deficiency in chronic HF.

L-Arginine supplementation enhanced expression of glucose transporter (GLUT 1) in sickle cell anaemia subjects in the steady state.

L-Arginine may have therapeutic value in the management of sickle cell disease and diabetes mellitus. There is very little information on the interaction of GLUT 1 and L-Arginine in sickle cell disease subjects. This study compared the blood levels of Glut 1, fasting blood glucose (FBG) and fasting insulin (FIns) in non-sickle cell anaemia (HbAA) and sickle cell anaemia (HbSS) subjects in the steady state before and following L-Arginine supplementation (1 g/day for 6 weeks).

Health-Related Quality of Life Among Patients With Sickle Cell Disease in an Adult Hematology Clinic in a Tertiary Hospital in Lagos, Nigeria.

Background Sickle cell disease (SCD) is a genetic disease of public health concern. Improved quality healthcare has increased the life expectancy of these patients; however, they also face an increased frequency of vaso-occlusive crises and other SCD complications. These complications affect their quality of life, an area of care, which healthcare providers often overlook.

The anthropogenic consequences of energy consumption in the presence of uncertainties and complexities: evidence from World Bank income clusters.

In environmental management, many studies have examined the energy consumption-emission nexus in detail. However, for the first time in the literature, this study considers how the Economic Complexity Index (ECI) and economic policy uncertainty (EPU) moderate the contribution of energy consumption to emissions for the four World Bank Income clusters. The system generalised methods of moments are applied to data for 109 countries from 1996 to 2016.

Survey data on land tenure and food security among farming households in northern Nigeria.

This dataset presents data collected from the households' survey in Northern Nigeria to examine land tenure and property rights among smallholder rice farmers and the influence it has on household food security. Data collection was by personal interviews of adult members of the farmers' households, focusing on the households' socio-economics, United States Department of Agriculture'- 18 Household Food Security questions for households with children, land titling status and land tenure type on farmland cultivated during the 2016/17 farming season. The data were collected from 475 rice farmers selected by multistage sampling across 84 rice-growing communities, seven States and the three geopolitical zones in northern Nigeria.

Land tenure and property rights, and household food security among rice farmers in Northern Nigeria.

There are growing campaigns to promote land titling to secure Land Tenure and Property Rights (LTPRs) in African agriculture. Theoretically, deed registration should reduce land disputes, facilitate land use as collateral for loans, and stimulate investment in land improvement for increased productivity, income and food security. Empirical evidence in these regards, however, remains anecdotal, and sometimes conflicting.

Ocular manifestations of leukaemia: A teaching hospital experience.

Background: Knowledge of the ophthalmic manifestations of leukaemia is important not only because of the frequency with which changes are seen but because the eye often reflects the disease state of the illness, and once identified, prompt referral, early treatment can be instigated, blindness can be averted and a life may be saved. These manifestations are often overlooked because of the underestimation of the magnitude of the ocular sequelae which may be blinding.

Aim: This study aims to describe the ophthalmic findings in adult leukaemic patients at two teaching hospitals in Lagos, Nigeria.

Prevalence of vitamin B deficiency among metformin-treated type 2 diabetic patients in a tertiary institution, South-South Nigeria.

Background: The risk of chronic metformin pharmacotherapy to cause vitamin B deficiency and its associated medical complications has been of immense concern among diabetic patients. Some studies have postulated that vitamin B deficiency is highly prevalent among chronic metformin-treated adult diabetic patients.

Aim: This study aimed to determine the prevalence of vitamin B deficiency among metformin-treated and metformin-naïve type 2 diabetes mellitus patients.

Supplementation with l-arginine stabilizes plasma arginine and nitric oxide metabolites, suppresses elevated liver enzymes and peroxidation in sickle cell anaemia.

The effect of l-arginine on liver function in SCD has received little or no attention. The effect of a chronic, oral, low-dose supplementation with l-arginine (1gm/day for 6 weeks) on some liver enzymes, lipid peroxidation and nitric oxide metabolites was studied in 20 normal (non-sickle cell anaemia; NSCA) subjects and 20 sickle cell anaemia (SCA) subjects. Ten milliliters of blood was withdrawn from an ante-cubital vein for the estimation of plasma arginine concentration ([R]), alanine aminotransaminase (ALT), aspartate aminotransaminase (AST) and alkaline phosphatase (ALP), plasma total bilirubin concentration [TB], malondialdehyde concentration [MDA] and nitric oxide metabolites concentration [NOx].

l-Arginine supplementation enhances antioxidant activity and erythrocyte integrity in sickle cell anaemia subjects.

The effect of oral, low-dose l-arginine supplementation (1g/day for 6 weeks) on antioxidant activity, haematological parameters and osmotic fragility of red blood cells was investigated in sickle cell disease sufferers. Twenty eight sickle cell anaemia subjects were recruited for the study. Five millilitres of blood was withdrawn from an ante-cubital vein for the estimation of plasma arginine concentration ([R]), total antioxidant enzymes (TAE) activity, malondialdehyde concentration ([MDA]), RBC count, [Hb], PCV, MCHC, MCV, MCH, percent irreversibly sickled cells (%ISC)) and osmotic fragility of red blood cells in the subjects.

Current sickle cell disease management practices in Nigeria.

Background: Although Nigeria has the highest burden of sickle cell disease (SCD) worldwide, there is still variable and poor utilisation of standard-of-care practices for SCD patients in the country.

Methods: This was a questionnaire survey of doctors in some dedicated SCD clinics in Nigeria in order to document the facilities available and common management practices.

Results: There were responses from 18 clinics based in 11 institutions.

L-arginine increases nitric oxide and attenuates pressor and heart rate responses to change in posture in sickle cell anemia subjects.

Pressor and heart rate changes following change in posture without or with L-arginine supplementation (1g/day for 6 weeks) were studied in 28 sickle cell anemia (SCA) and 32 non-sickle cell anemia (NSCA) subjects. Change in posture increased HR (p<0.01), RPP (p<0.

A prospective diary study of stuttering priapism in adolescents and young men with sickle cell anemia: report of an international randomized control trial--the priapism in sickle cell study.

Priapism is defined as a prolonged, persistent, and purposeless penile erection. It is a common (35%) but frequently understated complication in young men and adults with sickle cell disease. We had previously demonstrated an association between stuttering attacks (<4 hours) and an acute catastrophic event with its consequent problems of erectile dysfunction and impotence.

Liver enzymes and trace elements in the acute phase of sickle cell anaemia.

Background: Trace elements are required for the performance of numerous functions of immune cells. It is not clear whether levels of trace elements are elevated and whether there is a relationship between the levels of liver enzymes and trace elements in patients with sickle cell anaemia in crisis.

Objective: To compare the plasma levels of liver enzymes and trace elements in non sickle cell anaemia (NSCA), sickle cell anaemia subjects in the steady state (SCASS) and sickle cell anaemia patients in crisis (SCAC).

Electrocardiographic and blood pressure changes in apparently healthy male subjects following oral, chronic, low-dose vitamin C supplementation and/or change in posture.

Introduction: Studies have shown that oral, chronic, low dose vitamin C reduces blood pressure and forearm blood flow in normal young adults or hypertensive patients. It is not clear how vitamin C affects cardiac function or autonomic control of blood pressure in young apparently healthy adults.

Aim: This study was undertaken to examine the effects of a chronic, low dose (300 mg/day for 6 weeks) vitamin C supplementation on the electrocardiogram and autonomic control of blood pressure in apparently healthy male subjects.

Neurological complications of sickle cell anemia in Nigerian Africans--a case-control study.

Purpose: To determine the neurological complications associated with sickle cell anaemia (SCA) in Nigerians and evaluate the relative frequencies.

Methodology: Six-hundred-thirteen patients with SCA attending outpatient clinics of Lagos University Teaching Hospital and 616 control subjects were evaluated using a uniform structured questionnaire to determine the occurrence of neurological complications. The relative frequencies of neurological abnormalities in patients and controls were compared.

Effect of sodium salicylate iontophoresis in the management of hip pain in patients with sickle cell disease.

Background: Iotophoresis is a means of delivering drugs across the skin for the management of a variety of conditions, most often for localized inflammation and pain. It is becoming popular as an alternative to oral and injection delivery system because it is non-invasive, non-traumatic, and painless and also because of its specific delivery system.

Objective: The objective of this study was to determine the effectiveness of sodium salicylate iontophoresis in the management of hip pain in patient with sickle cell disorders (SCD).

Cardiac and autonomic responses to change in posture or vitamin C supplementation in sickle cell anemia subjects.

Autonomic function following change in posture with or without vitamin C supplementation was studied in ten (10) sickle cell anemia (SCA) and twelve (12) non-sickle cell anemia (NSCA) subjects. Arterial blood pressure and electrocardiographic measurements were taken in the supine position on a couch 80cm high and immediately on assumption of the upright position. Vitamin C was then administered orally (300mg/day for 6 weeks).

Hepatitis B and C virus infection in Nigerian patients with HIV/AIDS.

Objectives: This study was designed to assess the prevalence of HBV and HCV infection in HIV patients and evaluate the risk of infection compared with HIV negative control subjects.

Method: This is a prospective case control study in which 240 HIV/AIDS patients and age and sex matched controls were evaluated. The diagnosis of HIV infection was based on a positive HIV screening test using Capillus test kits (Trinity Biotech PLC, Ireland) and confirmed using Western blot assay.

Occlusal features of sickle cell anaemia patients in Lagos, Nigeria.

One hundred and four sickle cell anaemia patients aged 10-45 years and attending the out patients' clinic of the Lagos University Teaching Hospital as part of a routine check-up were seen. They were in a steady state of health. By means of a structured questionnaire the Biodata of each consecutive eligible patient was obtained and physical examination was carried out.

Effect of changes in plasma vitamin E level of vascular responses and lipid peroxidation in sickle cell anaemia subjects.

The effect of vitamin E supplementation (300 mg/day for 6 weeks) on blood pressure, forearm blood flow, forearm vascular resistance, plasma vitamin E level and lipid peroxidation status was investigated in adult sickle cell anaemia subjects. Ten adults whose ages ranged from 19.0 to 25.

Effect of acute uncomplicated malaria on platelet counts.

Objective: To determine the effect of uncomplicated malaria on platelet count.

Patients And Methods: Adult Nigerians (residing in the Lagos metropolis) who were diagnosed as having uncomplicated malaria were treated with a standard regime of chloroquine. Platelet counts were obtained before treatment, Day 0, and again on day 14 when parasitaemia had been cleared in the patients.

Ocular findings in sickle cell disease patients in Lagos.

Sickle cell disease has varied manifestations in all systems of the body, ocular manifestations can be severe and sudden blindness may result amidst other complications. The study aims at determining the ocular findings in patients with sickle cell anaemia (HbSS) and sickle cell haemoglobin C disease (HbSC). 99 subjects were recruited into the study carried out at the Lagos University Teaching Hospital over a 2 year period.