Publications by authors named "Kehao Peng"
LncRNAs are RNA transcripts that exceed 200 nucleotides in length and do not encode proteins. LINC00319 is a type of lncRNA that is highly expressed in various cancers and is regulated by CCL18 and MYC. High levels of LINC00319 are associated with poorer prognosis and more malignant clinical features in cancer patients.
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- Rifampicin (RIF) and multidrug-resistant tuberculosis (TB) pose significant public health challenges, and quicker diagnostic methods are needed compared to traditional testing that takes weeks.
- MeltPro TB and whole-genome sequencing (WGS) were evaluated for their effectiveness in detecting drug resistance to RIF, isoniazid (INH), and other medications in TB patients from Guangdong province.
- MeltPro TB demonstrated similar detection rates to WGS for RIF, INH, and streptomycin resistance, but its effectiveness for ethambutol (EMB) and fluoroquinolone (FQ) resistance was limited, indicating the need for further optimization before wider use.
Article Synopsis
- * This study utilized laboratory evolution to identify mutational pathways leading to amikacin resistance, finding that mutations affected susceptibility to other antibiotics such as isoniazid and levofloxacin.
- * Whole-genome sequencing revealed that the A1401G mutation predominates in resistant Mtb strains, which also exhibited distinct transcriptional profiles that suggest a competitive advantage in the presence of aminoglycosides.