Publications by authors named "Kefeng Guo"

Article Synopsis
  • Advanced lung adenocarcinoma (LUAD) patients with EGFR mutations often develop resistance to first-line EGFR-TKIs, highlighting the need for understanding resistance mechanisms and identifying biomarkers for better treatment strategies.
  • A study of 124 stage IV LUAD patients revealed common mutations in genes like TP53 and MYC, but the presence of certain mutations (PIK3C2G, STK11, EPAS1, BTG2) was specifically linked to poor progression-free survival (PFS) in those experiencing primary resistance to treatment.
  • Identifying these genomic variations helps clinicians predict which patients may not respond effectively to EGFR-TKIs and could guide us towards more personalized therapies.
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As a promising drug delivery system, the temperature-sensitive liquid embolic agent (TempSLE) has yet to be reported in animal experiments in treating gastric cancer. We observed and compared computed tomography (CT) imaging changes, tumor volume, HE staining, and immunohistochemistry after transcatheter arterial chemoembolization (TACE) treatment in rabbit VX2 gastric cancer models to clarify the effectiveness of TempSLE loaded with oxaliplatin (TempSLE/Oxa) in treating gastric cancer. One milliliter TempSLE can be loaded with 20 mg oxaliplatin.

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This study aim was to compare the safety and efficacy of combined transjugular/percutaneous intrahepatic portosystemic shunts (cTIPS) and transjugular intrahepatic portosystemic shunt (TIPS) in cirrhotic patients with cavernous transformation of the portal vein (CTPV) after conventional transjugular approach TIPS failure. Cirrhotic patients who were diagnosed as CTPV and treated by cTIPS or TIPS between July 2012 and April 2022 were retrospectively analyzed. Patients' characteristics and clinical data were recorded.

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Objective: Our aim is to evaluate the safety and efficacy of iodine-125 seed strand for intraluminal brachytherapy on ureteral carcinoma.

Methods: From November 2014 to November 2021, 22 patients with ureteral cancer not suitable for surgical resection were enrolled. Iodine-125 seed strand was inserted under c-arm CT and fluoroscopic guidance.

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This paper investigates the performance of a full-duplex (FD) relaying-enabled satellite sensor network under residual loop interference, where the satellite uplink and the downlink transmissions simultaneously occur over the same frequency band. Specifically, the closed-form expressions for the outage probability and ergodic capacity of the FD relaying satellite sensor network are derived by considering residual loop interference, channel statistical property, propagation loss, geometric satellite antenna pattern, and terminal elevation angle. Simulation results show the achieved performance gains of a full-duplex relaying satellite sensor network over traditional half-duplex relaying, and highlight the impact of key system parameters on the performance of the considered FD relaying satellite sensor network.

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This paper investigates the joint impact of channel estimation errors (CEEs) and hardware impairments (HIs) on the performance of a cognitive satellite-terrestrial relay network (CSTRN), where the terrestrial and satellite links are considered following Rayleigh fading and shadowed Rician (SR) fading distributions, respectively. Besides, the terrestrial relay is working in half-duplex decode-and-forward (DF) mode. By employing a general and practical model to account for both the CEEs and HIs at each link, the end-to-end signal-to-noise-plus-distortion-and-error ratio (SNDER) is first obtained for the CSTRN.

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In this paper, we investigate the performance of a two-way hybrid satellite multi-terrestrial cooperative network with hardware impairments (HIs). Particularly, opportunistic relay selection scheme is employed in the considered network, which can substantially enhance the spectral efficiency and spatial diversity gain. By considering both the amplify-and-forward (AF) and decode-and-forward (DF) relay protocols, the closed-form expressions of the outage probability (OP) and throughput for the system are derived.

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Objective: To analyze the influence of four types (class II long elastic, class II short elastic, class III long elastic, class III short elastic) of inter-arch elastics on the stress distribution and displacement of temporomandibular joint (TMJ).

Methods: To reconstruct a three-dimensional element model of left craniofacial bones with TMJ, maxilla, mandible and dentition with MBT straight wire appliance by CT images, Mimics, Ansys software. The influence of four types elastic on the model was analyzed by simulating the clinical conditions.

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