Lipoxin A4 promotes autophagy and inhibits overactivation of macrophage inflammasome activity induced by Pg LPS.

Objective: To explore the role of lipoxin A4 (LXA4) on inflammasome and inflammatory activity in macrophages activated by lipopolysaccharide (PgLPS) one of the major causative agents of chronic periodontitis.

Methods: The mouse macrophage cell line RAW264.7 was used to produce an activated inflammation model.

Nicorandil reversed homocysteine-induced coronary microvascular dysfunction via regulating PI3K/Akt/eNOS pathway.

Objective: Nicorandil exerts a protective effect against coronary microvascular dysfunction in acute myocardial infarction (AMI) patients. However, the mechanism and effect of nicorandil in hyperhomocysteinemia (HHcy) AMI patients remain unclear.

Methods: C57/BL6 mice with mild to moderate HHcy and human coronary artery endothelial cells (HCAECs) cotreated with HHcy (1 mmol/L) for 24 h and hypoxia for 6 h were selected as models.